- ►annals.org [PDF] RA DeFronzo - Annals of internal medicine, 1999 - Am Coll Physicians Type 2 diabetes mellitus is a chronic metabolic disorder that results from defects in both insulin
secretion and insulin action. An elevated rate of basal hepatic glucose production in the presence
of hyperinsulinemia is the pri- mary cause of fasting hyperglycemia; after a meal, im- ... Cited by 789 - Related articles - BL Direct - All 14 versions
- ►pharmyaring.com [PDF] SE Inzucchi - Jama, 2002 - Am Med Assoc Context Care of patients with type 2 diabetes has been revolutionized throughout the past several
years—first, by the realization of the importance of tight glycemic control in forestalling
complications, and second, by the availability of several unique classes of oral ... Cited by 608 - Related articles - BL Direct - All 18 versions
- ►karolinskauniversitetssjukhuset.se [PDF] SR Salpeter, E Greyber, GA Pasternak, EE … - Archives of Internal …, 2003 - archinte.highwire.org Methods A comprehensive search was performed to identify all comparative trials or observational
cohort studies published between January 1, 1959, and March 31, 2002, that evaluated metformin
therapy, alone or in combination with other treatments, for at least 1 month. The incidence ... Cited by 322 - Related articles - BL Direct - All 16 versions
- ►nursing2008.com RS Hundal, SE Inzucchi - Drugs, 2003 - ingentaconnect.com Metformin, a biguanide, has been available in the US for the treatment of type Abstract 2 diabetes
mellitus for nearly 8 years. Over this period of time, it has become the most widely prescribed
antihyperglycaemic agent. Its mechanism of action involves the suppression of ... Cited by 113 - Related articles - BL Direct - All 7 versions
M Riddle - The American journal of medicine, 2000 - Elsevier Type 2 diabetes mellitus is a progressive disorder, and although oral monotherapy is often initially
successful, it is associated with a high secondary failure rate, which contributes to the development
of long-term diabetes complications resulting from persistent hyperglycemia. For patients ... Cited by 97 - Related articles - All 5 versions
JL Chan, MJ Abrahamson - Mayo Clinic Proceedings, 2003 - mayoclinicproceedings.com Type 2 diabetes mellitus is a chronic metabolic disorder associated with high morbidity and mortality
from long- term microvascular and macrovascular complications. Evidence from randomized
controlled trials indicates that aggressive treatment directed at improving glycemic con- ... Cited by 76 - Related articles - View as HTML - BL Direct - All 12 versions
JB Buse, MH Tan, MJ Prince, PP … - Diabetes Obesity and …, 2004 - interscience.wiley.com Methods: medline was searched for entries indexed from January 1966 to November 2002; search
terms included the names of OAMs and serum lipids, limited to English language and human
subjects. We selected clinical studies in type 2 diabetes of OAM monotherapy that ... Cited by 69 - Related articles - BL Direct - All 4 versions
HE Lebovitz - Endocrinology and metabolism clinics of North America, 2001 - Elsevier The appropriate long-term management of hyperglycemia is critical for maintaining a normal
quality of life for the person with diabetes and for preventing the individual from developing the
acute and chronic complications of the disease. Most individuals with type 2 diabetes are ... Cited by 60 - Related articles - BL Direct - All 4 versions
D Porte Jr - Diabetes/metabolism research and reviews - ncbi.nlm.nih.gov Type 2 diabetes primarily develops from pathogenic defects in the mechanisms of insulin secretion
and hepatic and peripheral insulin action. The consequent disruption of normal glucose metabolism
involves a number of organ systems and is ultimately manifested in fasting and daytime ... Cited by 52 - Related articles - BL Direct - All 3 versions
