- ►uoguelph.ca [PDF] MJ Sheetz, GL King - Jama, 2002 - Am Med Assoc Diabetic complications are the major cause of morbidity and mortality in persons
with diabetes. Chronic hyperglycemia is a major initiator of diabetic
microvascular complications (eg, retinopathy, neuropathy, nephropathy). ... Cited by 375 - Related articles - BL Direct - All 6 versions
S Miyamoto - etp, 2002 - informahealthcare.com The development of long-term diabetic complications in diabetes patients is
considered to be closely related to hyperglycaemia. Aldose reductase was first
found to be implicated in the aetiology of secondary complications of ... Cited by 28 - Related articles - All 3 versions
D Podwall, C Gooch - Current Neurology and Neuroscience Reports, 2004 - Springer Introduction Diabetes mellitus is a common disease and continues to be a major
source of morbidity and mortality around the globe, despite remarkable advances
in our understanding of its pathogenesis and increasingly effective ... Cited by 19 - Related articles - BL Direct - All 2 versions
O El-Kabbani, C Darmanin, TR Schneider, I … - trials - www-bio3d-igbmc.u-strasbg.fr ABSTRACT The X-ray structures of human al- dose reductase holoenzyme in complex
with the inhibi- tors Fidarestat (SNK-860) and Minalrestat (WAY-509) were
determined at atomic resolutions of 0.92 Å and 1.1 Å, respectively. The ... Cited by 19 - Related articles - View as HTML - BL Direct - All 6 versions
C Gooch, D Podwall - Neurologist, 2004 - pdfs.journals.lww.com Background: Diabetes remains the most common cause of neurop- athy in the United
States and is a significant source of morbidity and mortality, accounting for
substantial suffering and billions of dollars in health care expenditures ... Cited by 17 - Related articles - All 3 versions
H Steuber, M Zentgraf, A Podjarny, A Heine, … - Journal of molecular biology, 2006 - Elsevier The crystal structure of a novel sulfonyl-pyridazinone inhibitor in complex with
aldose reductase, the first enzyme of the polyol pathway, has been determined to
1.43 Å and 0.95 Å resolution. The ternary complex of inhibitor, cofactor ... Cited by 16 - Related articles - All 4 versions
JT Millington, J Ellenzweig - Comprehensive therapy, 2005 - Springer The authors have stated that they do not have a significant financial interest
or other relationship with any product manufacturer or provider of services
discussed in this article. The authors also do not discuss the use of ... Cited by 8 - Related articles - All 4 versions
J Nakamura, Y Hamada, S Chaya, E Nakashima … - Diabetes/Metabolism Reviews - interscience.wiley.com The transition metal-catalyzed reaction is a major source of oxygen free
radicals, which play an important role in vascular dysfunction leading to
ischemia in diabetic tissues. The inhibition of polyol pathway ... Cited by 8 - Related articles - BL Direct - All 3 versions
