- ►endojournals.org H Wang, WS Chu, C Hemphill, SC Elbein - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Insulin resistance is strongly associated with obesity, but even among obese
subjects insulin sensitivity varies widely. Recently, a new adipocyte hormone,
resistin, was identified, shown to reduce insulin-mediated glucose uptake, ... Cited by 136 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org H Wang, H Zhang, Y Jia, Z Zhang, R Craig, X … - Diabetes, 2004 - Am Diabetes Assoc Considerable data support adiponectin as an important adipose-derived insulin
sensitizer that enhances fatty acid oxidation and alters hepatic
gluconeogenesis. Adiponectin acts by way of two receptors, ADIPOR1 and ... Cited by 70 - Related articles - BL Direct - All 5 versions
- ►endojournals.org SC Elbein, W Chu, Q Ren, C Hemphill, J … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc The calpain-10 gene (CAPN10) has been implicated in type 2 diabetes (T2DM)
susceptibility by both linkage and association in a Hispanic population from
Starr County Texas. Common intronic variants seem to alter CAPN10 mRNA ... Cited by 68 - Related articles - BL Direct - All 6 versions
- ►physiology.org H Wang, WS Chu, T Lu, SJ Hasstedt, PA Kern, … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc The onset of type 2 diabetes (T2DM) is preceded by obesity, insulin resistance,
and impaired -cell function. Uncoupling protein-2 (UCP2) is a widely expressed
inner mitochondrial membrane protein. Common polymorphisms of the UCP2 gene ... Cited by 62 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org W Winckler, MN Weedon, RR Graham, SA … - Diabetes, 2007 - Am Diabetes Assoc An important question in human genetics is the extent to which genes causing
monogenic forms of disease harbor common variants that may contribute to the
more typical form of that disease. We aimed to comprehensively evaluate the ... Cited by 56 - Related articles - BL Direct - All 5 versions
- ►endojournals.org SC Elbein - Endocrinology, 2002 - ncbi.nlm.nih.gov Twin and family studies have demonstrated a strong genetic component to type 2
diabetes mellitus (T2DM), but mapping the susceptibility genes that account for
this risk has proved difficult. At least seven single gene defects are ... Cited by 52 - Related articles - BL Direct - All 3 versions
RM Van Dam, B Hoebee, JC Seidell, MM … - Diabet Med, 2005 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 41 - Related articles - All 4 versions
- ►diabetesjournals.org H Wang, W Chu, SK Das, Q Ren, SJ Hasstedt, … - Diabetes, 2002 - Am Diabetes Assoc Pyruvate kinase is a key glycolytic enzyme. Isoforms that are expressed in the
red cell, liver, pancreatic β-cells, small intestine, and proximal renal tubule
are encoded by the 12 exons of the PKLR gene, which maps to chromosome ... Cited by 27 - Related articles - BL Direct - All 4 versions
- ►endojournals.org H Zhang, Y Jia, JJ Cooper, T Hale, Z Zhang, … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Increased flux of glucose through the hexosamine biosynthetic pathway has been
implicated in insulin resistance, altered insulin secretion, and diabetic
nephropathy. Glutamine:fructose-6-phosphate amidotransferase (GFPT), the ... Cited by 26 - Related articles - BL Direct - All 4 versions
SK Das, SC Elbein - Cellscience, 2006 - pubmedcentral.nih.gov Type 2 Diabetes results from a complex physiologic process that includes the
pancreatic beta cells, peripheral glucose uptake in muscle, the secretion of
multiple cytokines and hormone-like molecules from adipocytes, hepatic ... Cited by 25 - Related articles - All 3 versions
