AL Gloyn - Human mutation, 2003 - interscience.wiley.com Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a
crucial role in the regulation of insulin secretion and has been termed the
pancreatic beta-cell sensor. Given its central role in the regulation of ... Cited by 121 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org MCY Ng, WY So, NJ Cox, VKL Lam, CS Cockram … - Diabetes, 2004 - Am Diabetes Assoc We conducted an autosomal genome scan to map loci for type 2 diabetes in a Hong
Kong Chinese population. We studied 64 families, segregating type 2 diabetes, of
which 57 had at least one member with an age at diagnosis of ≤40 years. ... Cited by 48 - Related articles - BL Direct - All 6 versions
- ►nih.gov MCY Ng, KS Park, B Oh, CHT Tam, YM Cho, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— We confirmed the associations of TCF7L2, SLC30A8, HHEX, CDKAL1,
CDKN2A/CDKN2B, IGF2BP2, and FTO with risk for type 2 diabetes, with odds ratios
ranging from 1.13 to 1.35 (1.3 × 10 −12 < P unadjusted < 0.016). In ... Cited by 51 - Related articles - All 4 versions
S Ellard, K Colclough - Human mutation, 2006 - interscience.wiley.com Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes
mellitus characterized by autosomal dominant inheritance, early age of onset
(often <25 years of age), and pancreatic -cell dysfunction. MODY is both ... Cited by 32 - Related articles - BL Direct - All 4 versions
JA Rull, CA Aguilar-Salinas, R Rojas, JM Rios … - Archives of medical research, 2005 - Elsevier The epidemiology of diabetes in Mexico is reviewed. In less than four decades,
diabetes has become the main health problem in Mexico. It is the principal cause
of death in women and the second among men since the year 2000. It is the ... Cited by 32 - Related articles - All 13 versions
CA Aguilar-Salinas, R Rojas, FJ Gómez-Pérez, E … - The American journal of medicine, 2002 - Elsevier We identified 993 subjects with type 2 diabetes, including 143 subjects aged 20
to 39 years (14% of those with diabetes). Subjects with early-onset diabetes had
a greater prevalence of obesity and higher plasma insulin and lipid levels ... Cited by 27 - Related articles - All 11 versions
G Velho, P Froguel, A Gloyn, A Hattersley, 2004 - content.karger.com Karger is a medical publisher, scientific publisher and biomedical
publisher of print and online journals and books.
Cited by 20 - Related articles - BL Direct - All 3 versions
JM Cruickshank - Cardiovascular Drugs and Therapy, 2002 - Springer Summary. Type 2 diabetes is becoming very common and is closely linked to
physical inactivity and obesity. It is asso- ciated with clustering of coronary
risk factors and 60–80% of cases have hypertension. The first therapeutic ... Cited by 18 - Related articles - BL Direct - All 4 versions
L Molyneaux, M Constantino, D Yue - Diabetes Obesity and Metabolism, 2004 - interscience.wiley.com Research design and methods: Data on family history of diabetes and age of
diabetes onset were prospectively collected on 5193 subjects. Family members
were deemed to include grandparents, parents, siblings, aunts/uncles and ... Cited by 16 - Related articles - BL Direct - All 3 versions
JY Xu, QH Dan, V Chan, NMS Wat, S Tam, SC … - European Journal of Human Genetics, 2004 - nature.com In Caucasians, maturity-onset diabetes of the young (MODY) is mostly caused by
mutations in the hepatocyte nuclear factor (HNF)-1 (MODY3) and glucokinase
(MODY2) genes. Most Japanese MODY patients, however, are not linked to ... Cited by 17 - Related articles - All 4 versions
