MD Evans, M Dizdaroglu, MS Cooke - Mutation Research-Reviews in Mutation Research, 2004 - Elsevier The generation of reactive oxygen species may be both beneficial to cells,
performing a function in inter- and intracellular signalling, and detrimental,
modifying cellular biomolecules, accumulation of which has been associated ... Cited by 256 - Related articles - All 5 versions
RP Robertson, J Harmon, POT Tran, V Poitout - Diabetes, 2004 - Am Diabetes Assoc The relentless decline in β-cell function frequently observed in type 2
diabetic patients, despite optimal drug management, has variously been
attributed to glucose toxicity and lipotoxicity. The former theory posits ... Cited by 202 - Related articles - BL Direct - All 5 versions
LL Wu, CC Chiou, PY Chang, JT Wu - Clinica Chimica Acta, 2004 - Elsevier Reactive oxygen species (ROS) produced either endogenously or exogenously can
attack lipid, protein and nucleic acid simultaneously in the living cells. In
nuclear and mitochondrial DNA, 8-hydroxydeoxyguanosine (8-OHdG), an ... Cited by 150 - Related articles - All 8 versions
MG Andreassi - Mutation Research-Reviews in Mutation Research, 2003 - Elsevier Coronary artery disease (CAD) is a multifactorial process that appears to be
caused by the interaction of environmental risk factors with multiple
predisposing genes. Genetic research on CAD has traditionally focused on ... Cited by 70 - Related articles - All 6 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that
are proposed to play a role in all forms of type 2 diabetes. The underlying
concept is that once the primary pathogenesis of diabetes is established, ... Cited by 71 - Related articles - BL Direct - All 7 versions
RP Robertson, JS Harmon - Free Radical Biology and Medicine, 2006 - Elsevier Diabetes is commonly referred to in terms of type 1 and type 2. Both forms
involve pancreatic islet β-cell abnormalities, characterized by death in type 1
and accelerated apoptosis in type 2. The resultant chronic hyperglycemia ... Cited by 63 - Related articles - All 3 versions
M Kakimoto, T Inoguchi, T Sonta, HY Yu, M … - Diabetes, 2002 - Am Diabetes Assoc Oxidative stress may contribute to the pathogenesis of diabetic nephropathy.
However, the detailed molecular mechanism remains uncertain. Here, we report
oxidative mitochondrial DNA (mtDNA) damage and accumulation of mtDNA with a ... Cited by 61 - Related articles - BL Direct - All 5 versions
MS Cooke, J Lunec, MD Evans - Free Radical Biology and Medicine, 2002 - Elsevier Oxidative DNA damage has been implicated to be important in the pathogenesis of
many diseases, including cancer and heart disease. The assessment of damage in
various biological matrices, such as DNA, serum, and urine, is vital to ... Cited by 51 - Related articles - All 5 versions
KS Park, JH Kim, MS Kim, JM Kim, SK Kim, … - Diabetes, 2001 - Am Diabetes Assoc Cumulating evidence suggests that enhanced oxidative stress may contribute to
diabetic angiopathy. The levels of 8-hydroxydeoxyguanosine (8-OHdG) and
8-hydroxyguanine (8-OHG), indicators of oxidative DNA damage, in tissue or ... Cited by 45 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org P Wentzel, A Ejdesjö, UJ Eriksson - Diabetes, 2003 - Am Diabetes Assoc The aim of the present study was to investigate whether diabetic embryopathy may
be associated with the inhibition of glyceraldehyde-3-phosphate dehydrogenase
(GAPDH) resulting from an excess of reactive oxygen species (ROS) in the ... Cited by 36 - Related articles - BL Direct - All 5 versions
