- ►pnas.org ME Patti, AJ Butte, S Crunkhorn, K Cusi, … - Proceedings of the …, 2003 - National Acad Sciences Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell
dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal
muscle. Impaired insulin-mediated signaling, gene expression, glycogen synthesis, and ... Cited by 667 - Related articles - BL Direct - All 15 versions
JA Armitage, IY Khan, PD Taylor, PW … - The Journal of …, 2004 - Physiological Soc The incidence of the metabolic syndrome, a cluster of abnormalities focusing on insulin resistance
and associated with high risk for cardiovascular disease and diabetes, is reaching epidemic
proportions. Prevalent in both developed and developing countries, the metabolic ... Cited by 143 - Related articles - All 10 versions
- ►physiology.org PD Taylor, J McConnell, IY Khan, K … - American Journal of …, 2005 - Am Physiological Soc We previously reported that prenatal and suckling exposure to a maternal diet rich in animal
fat leads to cardiovascular dysfunction in young adult rat offspring with subsequent development
of dyslipidemia and hyperglycemia. We have further investigated glucose homeostasis in ... Cited by 83 - Related articles - All 5 versions
PD Taylor, L Poston - Experimental Physiology, 2007 - Physiological Soc Converging lines of evidence from epidemiological studies and animal models now indicate
that the origins of obesity and related metabolic disorders lie not only in the interaction between
genes and traditional adult risk factors, such as unbalanced diet and physical inactivity, ... Cited by 72 - Related articles - BL Direct - All 9 versions
- ►cnu.ac.kr [PDF] E Nisoli, E Clementi, S Moncada, MO Carruba - Biochemical pharmacology, 2004 - Elsevier The identification, more than 50 years ago, of mitochondria as the site of oxidative energy metabolism
has prompted studies that have unraveled the complexity of the numerous biosynthetic and degradative
reactions, fundamental to cell function, carried out by these organelles. These activities ... Cited by 52 - Related articles - All 5 versions
- ►physiology.org A Fleischman, S Johnsen, DM Systrom, M … - American Journal of …, 2007 - Am Physiological Soc Mitochondrial dysfunction may contribute to the development of insulin resistance and type 2
diabetes. Nucleoside reverse transcriptase inhibitors (NRTIs), specifically stavudine, are known
to alter mitochondrial function in human immunodeficiency virus (HIV)-infected ... Cited by 56 - Related articles - BL Direct - All 8 versions
- ►ahajournals.org E Nisoli, E Clementi, MO Carruba, S Moncada - Circulation research, 2007 - Am Heart Assoc The metabolic syndrome is a group of risk factors of metabolic origin that are accompanied by
increased risk for type 2 diabetes mellitus and cardiovascular disease. These risk factors include
atherogenic dyslipidemia, elevated blood pressure and plasma glucose, and a ... Cited by 47 - Related articles - All 6 versions
- ►pgd.org.uk [PDF] JML McConnell, L Petrie - Reproductive Biomedicine Online, 2004 - ingentaconnect.com Mitochondria are small endosymbiotic organelles that exist in almost all cell types and require
nuclear-encoded genes for activity (Attardi and Schatz, 1988). Originally thought to simply produce
energy, they are now known to influence vital processes in many different organs of the ... Cited by 34 - Related articles - All 3 versions
- ►nutrition.org KS Park, SK Kim, MS Kim, EY Cho, JH Lee, KU … - Journal of …, 2003 - Am Soc Nutrition Epidemiologic data suggest a strong association between low birth weight and increased risk
of metabolic syndrome in adult life. However, the underlying mechanisms are largely
unknown. To test the hypothesis that mitochondrial changes may serve as a link between ... Cited by 29 - Related articles - BL Direct - All 5 versions
- ►bu.edu [PDF] ME Patti - Current Opinion in Clinical Nutrition & Metabolic Care, 2004 - journals.lww.com Purpose of review Type 2 diabetes mellitus is characterized by insulin resistance and pancreatic
b-cell dysfunction. In high-risk individuals, the earliest detectable abnormality is insulin resistance
in skeletal muscle. Impaired insulin-mediated signaling, gene expression, and glycogen ... Cited by 26 - Related articles - BL Direct - All 4 versions
