- ►endojournals.org GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - Endocrine Soc The primary genetic, environmental, and metabolic factors responsible for causing insulin resistance
and pancreatic ß-cell failure and the precise sequence of events leading to the development
of type 2 diabetes are not yet fully understood. Abnormalities of triglyceride storage and ... Cited by 525 - Related articles - BL Direct - All 6 versions
JW Newcomer - CNS drugs, 2005 - ingentaconnect.com Increasing numbers of reports concerning diabetes, ketoacidosis, hyperglycaemia and lipid dysregulation
in patients treated with second-generation (or atypical) antipsychotics have raised concerns
about a possible association between these metabolic effects and treatment with these ... Cited by 356 - Related articles - All 6 versions
- ►cell.com P Arner - Trends in Endocrinology & Metabolism, 2003 - Elsevier Globally, the prevalence of obesity is escalating, and insulin resistance resulting from increased
(predominantly visceral) adipose tissue mass has been identified as a key factor that could drive
parallel rises in type 2 diabetes mellitus (T2DM) prevalence. Correlations between these ... Cited by 234 - Related articles - All 11 versions
- ►physiology.org DE Kelley, TM McKolanis, RAF Hegazi, … - American Journal of …, 2003 - Am Physiological Soc The current study was undertaken to examine metabolic and body composition correlates of
fatty liver in type 2 diabetes mellitus (DM). Eighty-three men and women with type 2 DM [mean
body mass index (BMI): 34 ± 0.5 kg/m 2 ] and without clinical or laboratory evidence of ... Cited by 196 - Related articles - BL Direct - All 3 versions
KR Short, JL Vittone, ML Bigelow, DN Proctor, RA … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance increases and muscle oxidative capacity decreases during aging, but lifestyle
changes—especially physical activity—may reverse these trends. Here we report the effect of
a 16-week aerobic exercise program (n = 65) or control activity (n = 37) performed by men ... Cited by 195 - Related articles - BL Direct - All 4 versions
E Bugianesi, AJ McCullough, G Marchesini… - Hepatology, 2005 - interscience.wiley.com Insulin resistance (IR) is the pathophysiological hallmark of nonalcoholic fatty liver disease
(NAFLD), one of the most common causes of chronic liver disease in Western countries. We
review the definition of IR, the methods for the quantitative assessment of insulin action, ... Cited by 170 - Related articles - BL Direct - All 3 versions
M Pravenec, L Kazdova, V Landa, V Zidek, P … - Journal of Biological …, 2003 - ASBMB Increased serum levels of resistin, a molecule secreted by fat cells, have been proposed as a
possible mechanistic link between obesity and insulin resistance. To further investigate the effects
of resistin on glucose metabolism, we derived a novel transgenic strain of spontaneously ... Cited by 111 - Related articles - BL Direct - All 4 versions
- ►physiology.org MW Hulver, JR Berggren, RN Cortright, … - American Journal of …, 2003 - Am Physiological Soc The objectives of this study were to 1) examine skeletal muscle fatty acid oxidation in individuals
with varying degrees of adiposity and 2) determine the relationship between skeletal muscle
fatty acid oxidation and the accumulation of long-chain fatty acyl-CoAs. Muscle was ... Cited by 105 - Related articles - BL Direct - All 6 versions
EH Koh, MS Kim, JY Park, HS Kim, JY Youn, HS Park, … - Diabetes, 2003 - Am Diabetes Assoc Lipid accumulation in nonadipose tissues is closely related to the development of type 2 diabetes
in obese subjects. We examined the potential preventive effect of peroxisome proliferator-activated
receptor (PPAR)-α and PPAR-γ stimulation on the development of diabetes in obese ... Cited by 104 - Related articles - BL Direct - All 6 versions
- ►physiology.org … , ML Parolin, GJF Heigenhauser, DJ Dyck - American Journal of …, 2002 - Am Physiological Soc The adipocyte-derived hormone leptin has been shown to acutely increase fatty acid (FA) oxidation
and decrease esterification in resting rodent skeletal muscle. However, the effects of leptin on
human skeletal muscle FA metabolism are completely unknown. In these studies, we ... Cited by 105 - Related articles - BL Direct - All 5 versions
