- ►physiology.org MJ Dunne, KE Cosgrove, RM Shepherd, A … - Physiological reviews, 2004 - Am Physiological Soc The earliest description of hyperinsulinism appears to have been that provided
by Laidlaw in 1938 who used the term nesidioblastosis to describe the severe,
recurrent hypoglycemia associated with an inappropriate elevation of serum ... Cited by 108 - Related articles - BL Direct - All 3 versions
- ►adisonline.com [PDF] M Rendell - Drugs, 2004 - ingentaconnect.com The sulphonylureas act by triggering insulin release from the pancreatic β
cell. Abstract A specific site on the adenosine triphosphate (ATP)-sensitive
potassium channels is occupied by sulphonylureas leading to closure of the ... Cited by 87 - Related articles - BL Direct - All 7 versions
- ►physiology.org H Huopio, SL Shyng, T Otonkoski, CG Nichols - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc ATP-sensitive potassium (K ATP ) channels are inhibited by intracellular ATP and
activated by ADP. Nutrient oxidation in -cells leads to a rise in [ATP]-to-[ADP]
ratios, which in turn leads to reduced K ATP channel activity, ... Cited by 61 - Related articles - BL Direct - All 6 versions
- ►endojournals.org H Huopio, J Jaaskelainen, J Komulainen, R … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Mutations in genes encoding the two subunits of the ß-cell ATP-sensitive
potassium channel (K ATP ) channel (SUR1 and Kir6.2) are the major cause of
congenital hyperinsulinism (CHI). In this study, the K ATP channel genes ... Cited by 21 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org LM t Hart, TW van Haeften, JM Dekker, M Bot … - Diabetes, 2002 - Am Diabetes Assoc An association between type 2 diabetes and genetic variation in the KIR6.2 gene
has been reported in several populations. Based on in vitro studies with cell
lines expressing the Glu 23 Lys (E23K) mutation, it was recently suggested ... Cited by 19 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org MS Remedi, J Koster… - Diabetes, 2004 - Am Diabetes Assoc ATP-sensitive K + channels (K ATP channels) control electrical activity in
β-cells and therefore are key players in excitation-secretion coupling. Partial
suppression of β-cell K ATP channels in transgenic (AAA) mice causes ... Cited by 17 - Related articles - BL Direct - All 5 versions
MS Remedi, JV Rocheleau, A Tong, BL Patton … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis ATP-sensitive K + (K ATP ) channels couple glucose
metabolism to insulin secretion in pancreatic beta cells. In humans,
loss-of-function mutations of beta cell K ATP subunits (SUR1, encoded by ... Cited by 13 - Related articles - BL Direct - All 4 versions
KE Cosgrove, RM Shepherd, EM Fernandez, A … - Horm Res, 2004 - content.karger.com Hyperinsulinism in infancy (HI) is a condition of neonates and early childhood.
For many years the pathophysiology of this potentially lethal disorder was
unknown. Advances in the genetics, histopathology and molecular physiology ... Cited by 12 - Related articles - BL Direct - All 5 versions
T Laitinen, H Huopio, I Vauhkonen, C Camaro, … - Clinical Science, 2003 - cs.portlandpress.com The effects of hypoglycaemia during hyperinsulinaemia, occurring under various
pathophysiological conditions, on the cardiovascular regulatory system and
vasculature are largely unknown. The aim of the present study was to ... Cited by 10 - Related articles - Cached - BL Direct - All 10 versions
T Laitinen, T Lyyra-Laitinen, H Huopio, I … - International Journal of Cardiology, 2007 - Elsevier Although cardiac beat interval remained unchanged, PR-interval decreased (P <
0.01) and QT- (P < 0.05) as well as QTc-intervals (P < 0.001) increased in
response to hyperinsulinemic hypoglycaemia. Concomitant morphological ... Cited by 8 - Related articles - BL Direct - All 4 versions
