- ►nih.gov DI Godfrey, M Kronenberg - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation of
immune responses associated with a broad range of diseases, including autoimmunity, infectious
diseases, and cancer. In stark contrast to both conventional T lymphocytes and other ... Cited by 348 - Related articles - BL Direct - All 10 versions
KJL Hammond, M Kronenberg - Current opinion in immunology, 2003 - Elsevier Natural killer T (NKT) cells are a unique lymphocyte subtype implicated in the regulation of
autoimmunity, particularly diabetes and experimental allergic encephalomyelitis in animal
models. In some reports, NKT-cell regulation was revealed only following vigorous ... Cited by 89 - Related articles - All 4 versions
- ►uhasselt.be [PDF] L Linsen, V Somers, P Stinissen - Human immunology, 2005 - Elsevier Natural killer T (NKT) cells are a conserved subpopulation of lymphocytes that recognize glycolipid
antigens in a CD1d context. Upon activation through their semi-invariant T cell receptor, these
cells rapidly release large amounts of immunomodulating Th1 and Th2 cytokines. NKT ... Cited by 37 - Related articles - All 6 versions
- ►jimmunol.org N Duarte, M Stenstrom, S Campino, ML … - The Journal of …, 2004 - Am Assoc Immnol A role for regulatory lymphocytes has been demonstrated in the pathogenesis of type 1 diabetes
in the NOD mouse but the nature of these cells is debated. CD1d-restricted NKT lymphocytes
have been implicated in this process. Previous reports of reduced diabetes incidence in ... Cited by 35 - Related articles - BL Direct - All 5 versions
- ►cell.com LT Mars, J Novak, RS Liblau, A Lehuen - Trends in immunology, 2004 - Elsevier Invariant NKT (iNKT) cells are a unique T cell subset that upon activation promptly produce copious
amounts of pro- and anti-inflammatory cytokines, thereby contributing to both innate and acquired
immunity. Animal models of autoimmune diseases suggest that iNKT cells favor immune ... Cited by 33 - Related articles - All 5 versions
S Miyake, T Yamamura - … Drug Targets-Immune, Endocrine &# 38; …, 2005 - ingentaconnect.com Abstract: NKT cells emerge as important regulatory cells in autoimmune responses. Abnormalities
in the numbers and functions of natural killer T (NKT) cells have been observed in patients with
autoimmune diseases as well as in a variety of mouse strains that are genetically ... Cited by 30 - Related articles - BL Direct - All 2 versions
SP Berzins, K Kyparissoudis, DG Pellicci, … - Immunology and cell …, 2004 - interscience.wiley.com Summary In the diabetes-prone NOD mouse, there is a proven association between a systemic
deficiency of NKT cells and the onset of type 1 diabetes. Numerous reports of similar defects
within the NKT cell compartment of human type 1 diabetes patients suggested NKT cell ... Cited by 30 - Related articles - BL Direct - All 5 versions
SL Cardell - Clinical and Experimental Immunology, 2006 - pubmedcentral.nih.gov Manipulation of the immune response to specifically prevent autoaggression requires an understanding
of the complex interactions that occur during the pathogenesis of autoimmunity. Much attention
has been paid to conventional T lymphocytes recognizing peptide antigens presented by ... Cited by 28 - Related articles - BL Direct - All 5 versions
J Novak, T Griseri, L Beaudoin, A … - International Reviews of …, 2007 - informahealthcare.com Type 1 diabetes is an autoimmune disease due to the destruction of insulin-producing pancreatic
β cells. Natural Killer T (NKT) cells are a T-cell subset that links the innate and adaptive immune
systems. NKT cells play a key regulatory role in type 1 diabetes. The absence of NKT ... Cited by 11 - Related articles - All 4 versions
PL Bollyky, SB Wilson - Immunology and cell biology, 2004 - nature.com CD1-restricted T cells have been shown to play a critical role in host defence, tumour
surveillance, and maintenance of tolerance. However, immunologic outcomes resulting from
activation of CD1d-restricted T cells can be either beneficial or deleterious. A major ... Cited by 9 - Related articles - BL Direct - All 5 versions
