G Alberti, P Zimmet, J Shaw, Z Bloomgarden, F … - Diabetes Care, 2004 - Am Diabetes Assoc The overall global prevalence of type 2 diabetes is rising steadily. Previously, type 2 diabetes was
predominantly a disease of middle-aged and older people. In recent decades, the age of onset has
decreased and type 2 diabetes has ... Cited by 143 - Related articles - BL Direct - All 6 versions
S Ellard, K Colclough - Human mutation, 2006 - interscience.wiley.com Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes mellitus characterized
by autosomal dominant inheritance, early age of onset (often <25 years of age), and pancreatic -cell
dysfunction. MODY is both ... Cited by 33 - Related articles - BL Direct - All 4 versions
FMA Giuffrida, AF Reis - Diabetes Obesity and Metabolism, 2005 - interscience.wiley.com Genetic factors play an important role in various forms of diabetes mellitus (DM), but inheritance
is complex and interacts with environmental factors. Although in most cases type 2 DM (T2DM) and
T1DM are polygenic disorders, ... Cited by 32 - Related articles - All 4 versions
- ►endojournals.org LS Fetita, E Sobngwi, P Serradas, F Calvo, JF … - Journal of Clinical …, 2006 - Endocrine Soc Evidence synthesis: Human studies performed in children and adolescents suggest that offspring who
had been exposed to maternal diabetes during fetal life exhibit higher prevalence of impaired
glucose tolerance and markers of ... Cited by 31 - Related articles - BL Direct - All 4 versions
R Murphy, S Ellard, AT Hattersley - Nature Clinical Practice Endocrinology …, 2008 - nature.com Sian Ellard is Professor of Human Molecular Genetics, Peninsula Medical School, Exeter, UK.
Following research training at the University of Swansea (UK), she set up the Molecular Genetics
Laboratory in Exeter with Professor ... Cited by 31 - Related articles - BL Direct - All 6 versions
D Dabelea - Diabetes Care, 2007 - Am Diabetes Assoc The hypothesis of fuel-mediated teratogenesis (1) proposes that intrauterine exposure to an excess
of fuels (for example, glucose) causes permanent fetal changes. In pregnancies complicated by
diabetes, this would lead to ... Cited by 29 - Related articles - BL Direct - All 6 versions
- ►robarts.ca [PDF] RA Hegele, B Zinman, AJG Hanley, SB Harris, PH … - Clinical biochemistry, 2003 - Elsevier The prevalence of type 2 diabetes in Canadian Oji-Cree is among the highest in the world. Our
research has uncovered genetic determinants of Oji-Cree type 2 diabetes and related metabolic
traits. The most important genetic ... Cited by 24 - Related articles - All 7 versions
- ►oxfordjournals.org LW Harries, S Ellard, A Stride… - Human Molecular Genetics, 2006 - Oxford Univ Press The generation of multiple transcripts by mRNA processing has the potential to moderate differences
in gene expression both between tissues and at different stages of development. Where gene function
is compromised by mutation, the ... Cited by 21 - Related articles - BL Direct - All 6 versions
L Eisenberg - The British Journal of Psychiatry, 2004 - RCP April 2003 marked the 50th anniversary of one of the great intellectual achievements of 20th century
biological science: deciphering of the DNA code by Jim Watson and Francis Crick (Watson & Crick,
1953). It is also the month and ... Cited by 17 - Related articles - BL Direct - All 5 versions
C Bellanné-Chantelot, C Carette, JP Riveline, R Valéro … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Missense mutations prevailed in the dimerization and DNA-binding domains (74%), while
truncating mutations were predominant in the transactivation domain (62%). The majority (83%) of the
mutations were located in exons 1- ... Cited by 15 - Related articles - BL Direct - All 4 versions
