SE Kahn - Diabetologia, 2003 - Springer The relative contributions of insulin resistance and be- ta-cell dysfunction to the pathophysiology
of Type 2 diabetes have been debated extensively. The concept that a feedback loop governs
the interaction of the in- sulin-sensitive tissues and the beta cell as well as the elucidation ... Cited by 517 - Related articles - BL Direct - All 6 versions
- ►harvard.edu [PDF] M Stumvoll, BJ Goldstein, TW van Haeften - The Lancet, 2005 - Elsevier Type 2 diabetes mellitus has become an epidemic, and virtually no physician is without patients
who have the disease. Whereas insulin insensitivity is an early phenomenon partly related to
obesity, pancreas β-cell function declines gradually over time already before the onset of ... Cited by 441 - Related articles - All 17 versions
SE Kahn, RL Hull, KM Utzschneider - NATURE-LONDON-, 2006 - tesumassd.org The increased prevalence of obesity has focused attention on a world- wide problem that is not
one of famine or infection, but one of surplus. In the United States, only about a third of adults
are considered to be of 'normal' weight1, and similar trends are being observed ... Cited by 294 - Related articles - View as HTML - BL Direct - All 9 versions
- ►endojournals.org RL Hull, GT Westermark, P Westermark, SE … - Journal of Clinical …, 2004 - Endocrine Soc Islet amyloid deposition is a pathogenic feature of type 2 diabetes, and these deposits contain
the unique amyloidogenic peptide islet amyloid polypeptide. Autopsy studies in humans have
demonstrated that islet amyloid is associated with loss of ß-cell mass, but a direct role for ... Cited by 120 - Related articles - BL Direct - All 6 versions
GDC Ball, MJ Weigensberg, ML Cruz, GQ Shaibi, … - International journal of …, 2005 - nature.com To examine cross-sectional differences in insulin sensitivity, insulin secretion and -cell function
during puberty in overweight Hispanic boys and girls with a family history of type 2 diabetes. ... This cross-sectional, observational study included 214 8–13-y-old Hispanic children ... Cited by 11 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Stadler, C Anderwald, T Karer, A Tura, T … - Diabetes care, 2006 - Am Diabetes Assoc RESULTS—PKT patients had higher fasting amylin (19 ± 3 vs. control subjects: 7 ± 1 pmol/l)
and insulin (20 ± 2 vs. control subjects: 10 ± 1 μU/ml; each P < 0.01) levels. Kidney transplant
subjects showed increased OGTT plasma insulin at 90 min and C-peptide levels (each P ... Cited by 12 - Related articles - BL Direct - All 6 versions
GS Jeha, RA Heptulla - Pediatric Diabetes, 2006 - interscience.wiley.com Abstract: Recent studies in adult patients with type 1 diabetes mellitus (T1DM) and T2DM have
examined the potential utility, benefits, and side effects of agents that augment insulin secretion
after oral ingestion of nutrients in comparison with intravenous nutrient delivery, the so- ... Cited by 7 - Related articles - BL Direct - All 3 versions
M Stumvoll, BJ Goldstein, TW van Haeften - Endocrine Research, 2007 - informahealthcare.com Insulin is the key hormone for regulating blood glucose. In general, normoglycemia is maintained
by the balanced interplay between insulin secretion and the efficacy of insulin actions. In the
fasting state, the major part of glucose is produced by the liver, and roughly half of it is ... Cited by 4 - Related articles - BL Direct - All 6 versions
JJ Hwang, JL Chan, G Ntali, D Malkova, CS … - Diabetes care, 2008 - Am Diabetes Assoc RESULTS—Amylin and pancreatic polypeptide levels increased 15 min after a 75-g glucose
load and remained elevated at 60 and 120 min (P < 0.0001). Fasting for 72 h decreased leptin
(to 21%) and amylin (to 67%) of baseline but not pancreatic polypeptide levels. ... Cited by 2 - Related articles - BL Direct - All 6 versions
R Valentino, GA Lupoli, GA Raciti, F Oriente, E Farinaro … - Diabetologia, 2006 - Springer Page 1. ARTICLE The PEA15 gene is overexpressed and related to insulin resistance
in healthy first-degree relatives of patients with type 2 diabetes R. Valentino & GA
Lupoli & GA Raciti & F. Oriente & E. Farinaro & E. Della ... Cited by 2 - Related articles - BL Direct - All 4 versions
