H Yki-Jarvinen - New England Journal of Medicine, 2004 - content.nejm.org Insulin resistance both precedes and predicts type 2 diabetes mellitus. 1
Although exercise and weight loss ameliorate insulin resistance and may in some
cases prevent or delay onset of the disease, 2 therapy that combats insulin ... Cited by 834 - Related articles - BL Direct - All 6 versions
M Cnop, PJ Havel, KM Utzschneider, DB Carr, … - Diabetologia, 2003 - Springer Aims/hypothesis. Increased intra-abdominal fat is as- sociated with insulin
resistance and an atherogenic li- poprotein profile. Circulating concentrations
of adip- onectin, an adipocyte-derived protein, are decreased with insulin ... Cited by 523 - Related articles - BL Direct - All 5 versions
SE Kahn - Diabetologia, 2003 - Springer The relative contributions of insulin resistance and be- ta-cell dysfunction to
the pathophysiology of Type 2 diabetes have been debated extensively. The
concept that a feedback loop governs the interaction of the in- ... Cited by 514 - Related articles - BL Direct - All 6 versions
JG Yu, S Javorschi, AL Hevener, YT … - Diabetes, 2002 - Am Diabetes Assoc The insulin-sensitizing effects of thiazolidinediones are thought to be mediated
through peroxisome proliferator-activated receptor-γ, a nuclear receptor that
is highly abundant in adipose tissue. It has been reported that adipocytes ... Cited by 445 - Related articles - BL Direct - All 5 versions
- ►eje-online.org [PDF] JJ Diez, P Iglesias - European Journal of Endocrinology, 2003 - EFES Adiponectin, also called GBP-28, apM1, AdipoQ and Acrp30, is a novel adipose
tissue-specific protein that has structural homology to collagen VIII and X and
complement factor C1q, and that circulates in human plasma at high levels. ... Cited by 440 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org M Chandran, SA Phillips, T Ciaraldi, RR … - Diabetes Care, 2003 - Am Diabetes Assoc Recent research has shown that adipose tissue is not simply an inert storage
depot for lipids but is also an important endocrine organ that plays a key role
in the integration of endocrine, metabolic, and inflammatory signals for ... Cited by 383 - Related articles - BL Direct - All 5 versions
PA Kern, GB Di Gregorio, T Lu, N Rassouli, … - Diabetes, 2003 - Am Diabetes Assoc Adiponectin is a 29-kDa adipocyte protein that has been linked to the insulin
resistance of obesity and lipodystrophy. To better understand the regulation of
adiponectin expression, we measured plasma adiponectin and adipose tissue ... Cited by 368 - Related articles - BL Direct - All 6 versions
O Tschritter, A Fritsche, C Thamer, M Haap, F … - Diabetes, 2003 - Am Diabetes Assoc In animals, the adipocyte-derived hormone adiponectin has been shown to improve
insulin sensitivity, a key factor in the pathogenesis of type 2 diabetes. In
Pima Indians, high plasma adiponectin levels are associated with increased ... Cited by 319 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org J Kim, M Montagnani, KK Koh, MJ Quon - Circulation, 2006 - Am Heart Assoc Endothelial dysfunction contributes to cardiovascular diseases, including
hypertension, atherosclerosis, and coronary artery disease, which are also
characterized by insulin resistance. Insulin resistance is a hallmark of ... Cited by 312 - Related articles - All 9 versions
- ►ahajournals.org M Furuhashi, N Ura, K Higashiura, H … - Hypertension, 2003 - Am Heart Assoc Adiponectin, an adipocyte-derived protein, has been suggested to play an
important role in insulin sensitivity. We examined the association between
insulin sensitivity (M value) evaluated by the euglycemic-hyperinsulinemic ... Cited by 306 - Related articles - BL Direct - All 15 versions
