- ►ahajournals.org SM Haffner, AS Greenberg, WM Weston, H Chen, K … - Circulation, 2002 - Am Heart Assoc Background— Markers of systemic inflammation (eg, C-reactive protein [CRP] and
interleukin-6 [IL-6]) have been proposed to be "nontraditional" risk factors for cardiovascular
disease in patients with type 2 diabetes mellitus. Matrix metalloproteinase-9 (MMP-9) has ... Cited by 837 - Related articles - BL Direct - All 9 versions
- ►ahajournals.org AH Berg, PE Scherer - Circulation Research, 2005 - Am Heart Assoc Mounting evidence highlights the role of adipose tissue in the development of a systemic inflammatory
state that contributes to obesity-associated vasculopathy and cardiovascular risk. Circulating
mediators of inflammation participate in the mechanisms of vascular insult and ... Cited by 442 - Related articles - All 10 versions
JC Pickup - Diabetes care, 2004 - Am Diabetes Assoc There is increasing evidence that an ongoing cytokine-induced acute-phase response (sometimes
called low-grade inflammation, but part of a widespread activation of the innate immune
system) is closely involved in the pathogenesis of type 2 diabetes and associated ... Cited by 365 - Related articles - BL Direct - All 8 versions
- ►ahajournals.org T McLaughlin, F Abbasi, C Lamendola, L Liang, G … - Circulation, 2002 - Am Heart Assoc Methods and Results— Plasma CRP concentrations were measured before and after 3 months
of calorie restriction in 38 healthy, obese women. Steady-state plasma glucose (SSPG) concentration
during a 180-minute infusion of octreotide, glucose, and insulin was used to stratify ... Cited by 246 - Related articles - BL Direct - All 7 versions
RM Krauss - Diabetes Care, 2004 - Am Diabetes Assoc Insulin resistance and type 2 diabetes are associated with a clustering of interrelated plasma
lipid and lipoprotein abnormalities, which include reduced HDL cholesterol, a predominance
of small dense LDL particles, and elevated triglyceride levels. Each of these dyslipidemic ... Cited by 183 - Related articles - BL Direct - All 6 versions
SA Phillips, TP Ciaraldi, APS Kong, R Bandukwala, V … - Diabetes, 2003 - Am Diabetes Assoc The relationship between insulin action and control of the adipocyte-derived factor adiponectin
was studied in age- and weight-matched obese individuals with type 2 diabetes failing sulfonylurea
therapy. After initial metabolic characterization, subjects were randomized to troglitazone ... Cited by 163 - Related articles - BL Direct - All 6 versions
SE Shoelson, L Herrero, A Naaz - Gastroenterology, 2007 - Elsevier Weight gain and obesity are major risk factors for conditions and diseases ranging from insulin
resistance and type 2 diabetes mellitus to atherosclerosis and the sequelae of nonalcoholic fatty
liver disease. A chronic, subacute state of inflammation often accompanies the ... Cited by 149 - Related articles - All 23 versions
MA Gonzalez, AP Selwyn - The American journal of medicine, 2003 - Elsevier Endothelial dysfunction may be evaluated by means of invasive techniques, such as coronary
artery reactivity to acetylcholine, or noninvasive techniques, such as brachial artery
ultrasonography. Loss of endothelium-dependent vasodilation is a characteristic feature ... Cited by 127 - Related articles - All 9 versions
H Kolb, T Mandrup-Poulsen - Diabetologia, 2005 - Springer Abstract Subclinical, low-grade systemic inflammation has been observed in patients with type
2 diabetes and in those at increased risk of the disease. This may be more than an
epiphenomenon. Alleles of genes encoding immune/ inflammatory mediators are ... Cited by 118 - Related articles - BL Direct - All 5 versions
- ►endojournals.org L Morin-Papunen, K Rautio, A Ruokonen, P … - Journal of Clinical …, 2003 - Endocrine Soc Low-grade chronic inflammation, reflected in elevated levels of serum C-reactive protein
(CRP), has recently been linked to obesity, insulin resistance syndromes such as polycystic ovary
syndrome (PCOS), and an increased risk of cardiovascular disease. Because the insulin ... Cited by 113 - Related articles - BL Direct - All 5 versions
