MA Creager, TF Luscher, F Cosentino, JA Beckman - Circulation, 2003 - Am Heart Assoc Diabetes mellitus affects approximately 100 million persons worldwide. 1 Five to ten percent
have type 1 (formerly known as insulin-dependent) and 90% to 95% have type 2
(non–insulin-dependent) diabetes mellitus. It is likely that the incidence of type 2 diabetes ... Cited by 405 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org NR Madamanchi, A Vendrov, MS Runge - … , thrombosis, and vascular …, 2005 - Am Heart Assoc Growing evidence indicates that chronic and acute overproduction of reactive oxygen species
(ROS) under pathophysiologic conditions is integral in the development of cardiovascular diseases
(CVD). These ROS can be released from nicotinamide adenine dinucleotide (phosphate) ... Cited by 362 - Related articles - All 10 versions
- ►ahajournals.org A Goldin, JA Beckman, AM Schmidt, MA Creager - Circulation, 2006 - Am Heart Assoc Advanced glycation end products (AGEs) are proteins or lipids that become glycated after exposure
to sugars. AGEs are prevalent in the diabetic vasculature and contribute to the development
of atherosclerosis. The presence and accumulation of AGEs in many different cell types ... Cited by 193 - Related articles - All 7 versions
F Fiordaliso, R Bianchi, L Staszewsky, I Cuccovillo, … - Journal of molecular and …, 2004 - Elsevier Diabetes and oxidative stress concur to cardiac myocyte death in various experimental
settings. We assessed whether N-acetyl-l-cysteine (NAC), an antioxidant and glutathione
precursor, has a protective role in a rat model of streptozotocin (STZ)-induced diabetes ... Cited by 62 - Related articles - All 7 versions
- ►diabetesjournals.org L Li, T Sawamura, G Renier - Diabetes, 2003 - Am Diabetes Assoc Endothelial dysfunction is an early and key determinant of diabetic vascular complications that
is elicited at least in part by oxidized LDL (oxLDL). The recent observation that lectin-like oxLDL
receptor-1 (LOX-1) expression is increased in the vascular endothelium of diabetic rats ... Cited by 55 - Related articles - BL Direct - All 4 versions
U Singh, I Jialal - Pathophysiology, 2006 - Elsevier Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the Western
world. Its incidence has been increasing lately in developing countries. Several lines of evidence
support a role for oxidative stress in atherogenesis. Growing evidence indicates that ... Cited by 54 - Related articles - All 10 versions
RMA Henry, I Ferreira, PJ Kostense, JM Dekker, G … - Atherosclerosis, 2004 - Elsevier Background: Type 2 diabetes (DM2) and impaired glucose metabolism (IGM) are associated
with an increased cardiovascular disease risk. Impaired endothelial synthesis of nitric oxide
(NO) is an important feature of atherothrombosis and can be estimated from endothelium- ... Cited by 51 - Related articles - All 9 versions
- ►asnjournals.org T Nakagawa, W Sato, O Glushakova, M … - Journal of the American …, 2007 - Am Soc Nephrol The pathogenesis of diabetic nephropathy remains poorly defined, and animal models that represent
the human disease have been lacking. It was demonstrated recently that the severe endothelial
dysfunction that accompanies a diabetic state may cause an uncoupling of the vascular ... Cited by 49 - Related articles - BL Direct - All 6 versions
A Rojas, MA Morales - Life sciences, 2004 - Elsevier The formation of advanced glycation end-products (AGEs), also called the Maillard reaction,
occurs ubiquitously and irreversibly in patients with diabetes mellitus, and its consequences
are especially relevant to vascular dysfunctions. The interaction of AGEs with their ... Cited by 49 - Related articles - All 6 versions
H Yki-Järvinen - Best Practice & Research Clinical Endocrinology & …, 2003 - Elsevier Insulin has multiple metabolic actions, including effects on blood vessels. Insulin normally increases
blood flow by a mechanism which involves generation of nitric oxide (NO) via the arginine–NO
pathway. Although insulin itself is a weak and physiologically unimportant vasodilatator, it ... Cited by 51 - Related articles - All 6 versions
