- ►endojournals.org MP Reilly, N Iqbal, M Schutta, ML Wolfe, M … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Leptin signaling may promote atherothrombosis and lead to cardiovascular
disease. However, whether leptin is associated with human atherosclerosis,
distinct from thrombosis, is unknown. We determined the association of ... Cited by 108 - Related articles - BL Direct - All 4 versions
- ►endojournals.org J Nigro, N Osman, AM Dart, PJ Little - Endocrine reviews, 2006 - Endocrine Soc In metabolic tissues, insulin signaling via the phosphatidylinositol-3-kinase
pathway leads to glucose uptake so that in insulin resistance a state of
hyperglycemia occurs; other factors such as dyslipidemia and hypertension ... Cited by 102 - Related articles - BL Direct - All 5 versions
J Beltowski - Atherosclerosis, 2006 - Elsevier Leptin, a 167-amino acid peptide hormone produced by white adipose tissue, is
primarily involved in the regulation of food intake and energy expenditure.
Leptin receptors are expressed in many tissues including the cardiovascular ... Cited by 92 - Related articles - All 18 versions
L Li, JC Mamputu, N Wiernsperger, G Renier - Diabetes, 2005 - Am Diabetes Assoc Accumulating evidence suggests that high concentrations of leptin observed in
obesity and diabetes may contribute to their adverse effects on cardiovascular
health. Metformin monotherapy is associated with reduced macrovascular ... Cited by 62 - Related articles - All 5 versions
C Herder, J Baumert, B Thorand, W Koenig, W … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: The chemokines monocyte chemoattractant protein-1
(MCP-1), IL-8 and interferon-γ- inducible protein-10 (IP-10) are released by
adipocytes and appear to be involved in atherosclerosis. We hypoth- esised ... Cited by 52 - Related articles - All 4 versions
E Simeoni, MM Hoffmann, BR Winkelmann, J … - Diabetologia, 2004 - Springer Aims/hypothesis. The molecular mechanisms of obesi- ty-related insulin
resistance are incompletely under- stood. Macrophages accumulate in adipose
tissue of obese individuals. In obesity, monocyte chemoattrac- tant ... Cited by 46 - Related articles - BL Direct - All 7 versions
R Wolk, VK Somers - Experimental Physiology, 2007 - Physiological Soc The metabolic syndrome represents a clustering of several interrelated risk
factors of metabolic origin that are thought to increase cardiovascular risk. It
is still uncertain whether this clustering results from multiple underlying ... Cited by 47 - Related articles - BL Direct - All 13 versions
- ►diabetesjournals.org C Cipolletta, KE Ryan, EV Hanna, ER Trimble - Diabetes, 2005 - Am Diabetes Assoc Blood levels of inflammatory markers associated with endothelial dysfunction and
atherosclerosis are increased in diabetic patients; the highest levels occur in
poorly controlled diabetes. We investigated the activation state of ... Cited by 36 - Related articles - BL Direct - All 5 versions
GH Goossens - Physiology & Behavior, 2008 - Elsevier Research of the past decade has increased our understanding of the role adipose
tissue plays in health and disease. Adipose tissue is now recognized as a highly
active metabolic and endocrine organ. Adipocytes are of importance in ... Cited by 37 - Related articles - All 4 versions
S Bansilal, ME Farkouh, V Fuster - The American Journal of Cardiology, 2007 - Elsevier Insulin resistance (IR) is the underlying defect in >90% of patients with type 2
diabetes mellitus and the major pathologic mechanism for the associated
susceptibility to premature cardiovascular disease (CVD). The progression ... Cited by 34 - Related articles - All 33 versions
