P Kurtzhals - International Journal of Obesity, 2004 - nature.com The suboptimal nature of the absorption profiles of human insulin formulations following subcutaneous
administration has prompted the development of insulin analogues better suited for therapeutic
use in diabetes mellitus. A particular challenge has been to engineer long-acting agents ... Cited by 65 - Related articles - BL Direct - All 5 versions
- ►adisonline.com [PDF] R Oiknine, M Bernbaum, AD Mooradian - Drugs, 2005 - pt.wkhealth.com Insulin is one of the oldest and best studied treatments for diabetes mellitus. Despite many improvements
in the management of diabetes, the nonphysiological time-action profiles of conventional insulins
remain a significant obstacle. However, the advent of recombinant DNA technology made ... Cited by 60 - Related articles - All 5 versions
P Home, P Kurtzhals - Expert Opin. Pharmacother., 2006 - Informa Pharma Science Insulin detemir (Levemir®, Novo Nordisk) is a novel, biologically engineered analogue of human
insulin that has been successfully developed for clinical use in diabetes as a basal insulin. Its
unique mechanism of prolongation of action, achieved through acylation to give ... Cited by 58 - Related articles - BL Direct - All 5 versions
KJ Robertson, E Schoenle, Z Gucev, L … - Diabetic …, 2007 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 54 - Related articles - BL Direct - All 5 versions
A Dornhorst, HJ Luddeke, S Sreenan, C … - … journal of clinical …, 2007 - interscience.wiley.com PREDICTIVE TM (Predictable Results and Experience in Diabetes through Intensification and
Control to Target: An International Variability Evaluation) is a large, multi-national,
open-label, prospective, observational study assessing the safety and efficacy of insulin ... Cited by 34 - Related articles - BL Direct - All 5 versions
FJ Gómez-Pérez, JA Rull - Archives of medical research, 2005 - Elsevier In normal humans, blood glucose and insulin are maintained within a narrow range despite wide
variations in physical activity and dietary intake. At present, reproducing this pattern is an impossible
task in type 1 diabetes and extremely difficult in type 2 DM. New approaches using novel ... Cited by 25 - Related articles - All 12 versions
H Soran, N Younis - Diabetes Obesity and Metabolism, 2006 - interscience.wiley.com Basal insulin therapy is an integral part of the intensive management of type 1 diabetes and it
is also often used in type 2 diabetes. An ideal insulin regimen in patients with diabetes would
mirror the 24-h insulin profile of a non-diabetic person, thereby preventing ... Cited by 19 - Related articles - BL Direct - All 4 versions
E Renard - Diabetes and Metabolism, 2005 - Elsevier Intensive insulin therapy aiming at normoglycemia in order to prevent long-term complications
is not questionable for the management of type 1 diabetes mellitus nowadays. The gold standard
mode of insulin therapy in this view is CSII using fast-acting analogues. Whether this ... Cited by 17 - Related articles - BL Direct - All 3 versions
