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Scholar Results 1 - 10 of about 52 citing Kipnes: Control of postprandial plasma glucose by an oral insulin product (HIM2) in patients.... (0.08 sec) 

Gateways to clinical trials


M Bayes, X Rabasseda, JR Prous - Methods and findings in …, 2006 - journals.prous.com
Contributing Editors: P. Cole, C. Orellana, JA Vallès, RM a . Antonijoan, KP Mohana Priya, M.
Priya, V. Renuga, R. Sree Lekha, B. Priya, A. Tomillero, G. Krithiga and E. Banu Rekha.
Cited by 148 - Related articles - All 9 versions

Alternative routes of insulin delivery


DR Owens, B Zinman, G Bolli - Diabetic Medicine, 2003 - interscience.wiley.com
Attempts at replicating physiological insulin secretion, as a means of restoring the normal
metabolic milieu and thereby minimizing the risk of diabetic complications, has become an essential
feature of insulin treatment. ...
Cited by 135 - Related articles - BL Direct - All 5 versions

Oral modified insulin (HIM2) in patients with type 1 diabetes mellitus: results from a …


S Clement, P Dandona, JG Still, G Kosutic - Metabolism, 2004 - Elsevier
An effective, orally administered insulin product would be of substantial benefit in the treatment
of patients with diabetes mellitus. This phase I/II clinical trial was the first to investigate the
safety and effectiveness of a ...
Cited by 43 - Related articles - All 10 versions

Is the oral route possible for peptide and protein drug delivery?

- utexas.edu [PDF] 
M Morishita, NA Peppas - Drug discovery today, 2006 - Elsevier
Oral delivery of peptides and proteins remains an attractive alternative to parenteral delivery and
has challenged various attempts at delivery development. Incorporation of new tools into the
delivery systems that can raise ...
Cited by 45 - Related articles - All 4 versions

Hydrogels for oral delivery of therapeutic proteins

- utexas.edu [PDF] 
NA Peppas, KM Wood, JO Blanchette - ebt, 2004 - Informa Pharma Science
In recent years there has been significant new interest in the development of transmucosal (mostly
oral) pharmaceutical formulations for the delivery of therapeutic proteins. Emphasis has been given
to the molecular design of new ...
Cited by 39 - Related articles - All 5 versions

Novel pharmacologic agents for type 2 diabetes


GI Uwaifo, RE Ratner - Endocrinology and metabolism clinics of North America, 2005 - Elsevier
Since the discovery of insulin by Banting and Best in the early 20th century, the clinical
management of diabetes has undergone significant changes. The last decade has been associated with
an explosion in therapeutic options ...
Cited by 38 - Related articles - All 3 versions

Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats


C Damge, P Maincent, N Ubrich - Journal of Controlled Release, 2007 - Elsevier
Nanoparticles prepared with a blend of a biodegradable polyester (poly(-ε-caprolactone)) and a
polycationic non-biodegradable acrylic polymer (Eudragit® RS) have been used as a drug carrier for
oral administration of insulin. The ...
Cited by 39 - Related articles - All 3 versions

Insulin therapy in type 2 diabetes

- hospitalprivadosa.com.ar [PDF] 
T Davis, SV Edelman - Medical Clinics of North America, 2004 - Elsevier
Type 2 diabetes leads to a tremendous amount of death and disability and uses a large portion of the
health care dollar [4]. Although diabetes is associated with multiple disorders with distinct
pathologic mechanisms, insulin ...
Cited by 25 - Related articles - BL Direct - All 4 versions

Strategies to improve oral drug bioavailability


I Gomez-Orellana - Expert Opin. Drug Deliv., 2005 - informahealthcare.com
Efforts to improve oral drug bioavailability have grown in parallel with the pharmaceutical
industry. As the number and chemical diversity of drugs has increased, new strategies have been
required to develop orally active ...
Cited by 24 - Related articles - BL Direct - All 4 versions

Oral Delivery of Insulin with the eligen () Technology: Mechanistic Studies


D Malkov, R Angelo, H Wang, E Flanders, H … - Current Drug …, 2005 - ingentaconnect.com
Page 1. Current Drug Delivery, 2005, 2, 191-197 191 1567-2018/05 $50.00+.00 © 2005 Bentham Science
Publishers Ltd. Oral Delivery of Insulin with the eligen ® Technology: Mechanistic Studies Dmitry Malkov,
Robert Angelo, Huai-zhen Wang, Elizabeth Flanders, Heather Tang and Isabel Gomez-Orellana * ...
Cited by 23 - Related articles - All 2 versions


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