DJ Drucker, MA Nauck - The Lancet, 2006 - Elsevier Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone that
stimulates insulin and suppresses glucagon secretion, inhibits gastric emptying,
and reduces appetite and food intake. Therapeutic approaches for enhancing ... Cited by 416 - Related articles - All 10 versions
B Ahrén, R Gomis, E Standl, D Mills, A … - Diabetes Care, 2004 - Am Diabetes Assoc RESULTS—In patients randomized to LAF237, baseline HbA 1c averaged 7.7 ± 0.1%
and decreased at week 12 (Δ = −0.6 ± 0.1%), whereas HbA 1c did not change
from a baseline of 7.9 ± 0.1% in patients given placebo (between-group ... Cited by 313 - Related articles - BL Direct - All 8 versions
- ►endojournals.org F Fehse, M Trautmann, JJ Holst, AE Halseth … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Context: First-phase insulin secretion (within 10 min after a sudden rise in
plasma glucose) is reduced in type 2 diabetes mellitus (DM2). The incretin
mimetic exenatide has glucoregulatory activities in DM2, including glucose- ... Cited by 123 - Related articles - BL Direct - All 4 versions
- ►endojournals.org BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc There is a progressive deterioration in ß-cell function and mass in type 2
diabetics. It was found that islet function was about 50% of normal at the time
of diagnosis, and a reduction in ß-cell mass of about 60% was shown at ... Cited by 105 - Related articles - BL Direct - All 7 versions
JJ Meier, MA Nauck - Diabetes/Metabolism Reviews - interscience.wiley.com Post-translational proteolytic processing of the preproglucagon gene in the gut
results in the formation of glucagon-like peptide 1 (GLP-1). Owing to its
glucose-dependent insulinotropic effect, this hormone was postulated to ... Cited by 73 - Related articles - All 3 versions
- ►physiology.org DA D'Alessio, TP Vahl - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Glucagon-like peptide 1 (GLP-1) is a product of proglucagon that is secreted by
specialized intestinal endocrine cells after meals. GLP-1 is insulinotropic and
plays a role in the incretin effect, the augmented insulin response ... Cited by 37 - Related articles - BL Direct - All 4 versions
RE Pratley, A Salsali - Current Medical Research and Opinion®, 2007 - informahealthcare.com University of Vermont College of Medicine, Burlington, VT, USA ... Address for
correspondence: Richard E. Pratley, MD, Professor of Medicine, Director –
Diabetes & Metabolism Translational Medicine Unit, Department of Medicine, ... Cited by 29 - Related articles - BL Direct - All 4 versions
- ►endojournals.org TP Vahl, M Tauchi, TS Durler, EE Elfers, TM … - Endocrinology, 2007 - Endocrine Soc Glucagon-like peptide-1 (GLP-1) is an intestinal hormone that is secreted during
meal absorption and is essential for normal glucose homeostasis. However, the
relatively low plasma levels and rapid metabolism of GLP-1 raise questions ... Cited by 28 - Related articles - BL Direct - All 2 versions
TP Vahl, DA D'Alessio - eid, 2004 - Informa Pharma Science It has been known for at least one century that agents secreted from the
intestine during meal absorption regulates glucose assimilation. Extensive
research during the past three decades has identified two gut hormones, ... Cited by 24 - Related articles - All 4 versions
