- ►shouxi.net A Garg - The New England journal of medicine, 2004 - nejm.org Lipodystrophies are clinically heterogeneous acquired or inherited disorders characterized by
the selective loss of adipose tissue. Affected patients are predisposed to insulin resistance and
its attendant complications, including diabetes mellitus, dyslipidemia, hepatic steatosis, ... Cited by 251 - Related articles - BL Direct - All 10 versions
KN Jacob, A Garg - Molecular Genetics and Metabolism, 2006 - Elsevier Laminopathies are a heterogeneous group of genetic disorders due to abnormalities in type
A lamins and can manifest varied clinical features affecting many organs including the skeletal
and cardiac muscle, adipose tissue, nervous system, cutaneous tissue, and bone. ... Cited by 46 - Related articles - All 3 versions
A Garg, A Misra - Endocrinology and metabolism clinics of North America, 2004 - Elsevier The metabolic syndrome or insulin resistance syndrome is defined in relationship to generalized
or regional adiposity. The criteria for definition of “metabolic syndrome” include measures of
obesity, such as waist circumference [1]. Although these definitions are appropriate for the ... Cited by 41 - Related articles - BL Direct - All 3 versions
- ►jlr.org RA Hegele, TR Joy, SA Al-Attar, BK Rutt - The Journal of Lipid Research, 2007 - ASBMB The lipodystrophies are characterized by loss of adipose tissue in some anatomical sites, frequently
with fat accumulation in nonatrophic depots and ectopic sites such as liver and muscle. Molecularly
characterized forms include Dunnigan-type familial partial lipodystrophy (FPLD), partial ... Cited by 29 - Related articles - All 7 versions
- ►endojournals.org KN Jacob, F Baptista, HG dos Santos, J Oshima … - Journal of Clinical …, 2005 - Endocrine Soc Context: A heterozygous missense mutation substituting arginine at position 133 to leucine in
the lamin A/C protein has been reported in two young women with clinical features of short
stature, bird-like faces, and early onset of aging processes. ... Objective: The objective of ... Cited by 16 - Related articles - BL Direct - All 4 versions
- ►endojournals.org A Decaudain, MC Vantyghem, B Guerci, AC … - Journal of Clinical …, 2007 - Endocrine Soc Results: LMNA mutations found in nine patients studied here affected the three protein
domains. Eight of them were novel. The 10 patients with non-codon 482-associated mutations
fulfilled the International Diabetes Federation diagnosis criteria for metabolic syndrome. ... Cited by 12 - Related articles - BL Direct - All 3 versions
- ►nih.gov JY Park, ED Javor, EK Cochran, AM DePaoli, P Gorden - Metabolism, 2007 - Elsevier The Dunnigan-type familial partial lipodystrophy (FPLD) is characterized by a variable loss of
fat from the extremities and trunk and excess subcutaneous fat in the chin and supraclavicular
area. Associated metabolic abnormalities include hypoleptinemia, insulin resistance, and ... Cited by 11 - Related articles - All 14 versions
A Garg, AK Agarwal - BBA-Molecular and Cell Biology of Lipids, 2009 - Elsevier The adipocytes synthesize and store triglycerides as lipid droplets surrounded by various proteins
and phospholipids at its surface. Recently, the molecular basis of some of the genetic syndromes
of lipodystrophies has been elucidated and some of these genetic loci have been found ... Cited by 6 - Related articles - All 2 versions
A Misra, A Jaiswal, D Shakti, J Wasir, NK Vikram, … - Diabetes Research and …, 2008 - Elsevier On univariate analysis, age more than 35 year, female gender, presence of buffalo hump and
double chin and family history of T2DM were significantly associated with the MS. A metabolic
syndrome screening (MSS) score (1.0 × double chin + 1.2 × buffalo hump + 1.3 × gender ... Cited by 3 - Related articles - All 21 versions
KM Wojtanik, K Edgemon, S Viswanadha, B … - The Journal of Lipid …, 2009 - ASBMB We investigated the role of LMNA in adipose tissue by developing a novel mouse model of
lipodystrophy. Transgenic mice were generated that express the LMNA mutation that causes
familial partial lipodystrophy of the Dunnigan type (FPLD2). The phenotype observed in ... Cited by 1 - Related articles - All 4 versions
