H Brunner, JR Cockcroft, J Deanfield, A Donald, … - Journal of …, 2005 - journals.lww.com Dysfunction of the vascular endothelium is a hallmark of most conditions that are associated
with atherosclerosis and is therefore held to be an early feature in atherogenesis. However, the
mechanisms by which endothelial dysfunction occurs in smoking, dyslipidaemia, ... Cited by 204 - Related articles - All 9 versions
AE Caballero - Obesity, 2003 - nature.com Obesity, insulin resistance, and endothelial dysfunction closely coexist throughout the natural
history of type 2 diabetes. They all can be identified not only in people with type 2 diabetes, but
also in various groups at risk for the disease, such as individuals with impaired glucose ... Cited by 182 - Related articles - BL Direct - All 7 versions
- ►ahajournals.org SS Najjar, A Scuteri, EG Lakatta - Hypertension, 2005 - Am Heart Assoc Age is the dominant risk factor for cardiovascular diseases. However, until recently, convincing
mechanistic or molecular explanations for the increased cardiovascular risks conferred by aging
have been elusive. Aging is associated with alterations in a number of structural and ... Cited by 179 - Related articles - All 8 versions
- ►diabetesjournals.org JR Singleton, AG Smith, JW Russell, EL Feldman - Diabetes, 2003 - Am Diabetes Assoc Impaired glucose tolerance (IGT) serves as a marker for the state of insulin resistance and predicts
both large- and small-vessel vascular complications, independent of a patient's progression
to diabetes. Patients with IGT are at significantly increased risk for death and morbidity ... Cited by 131 - Related articles - BL Direct - All 9 versions
- ►endojournals.org R Muniyappa, M Montagnani, KK Koh, MJ Quon - Endocrine reviews, 2007 - Endocrine Soc Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and subsequent
augmentation of glucose disposal in classical insulin target tissues (e.g., skeletal muscle). ... Cited by 101 - Related articles - BL Direct - All 5 versions
- ►endojournals.org V Fonseca, C Desouza, S Asnani, I Jialal - Endocrine reviews, 2004 - Endocrine Soc People with type 2 diabetes are disproportionately affected by cardiovascular disease
(CVD), compared with those without diabetes. Traditional risk factors do not fully explain this
excess risk, and other "nontraditional" risk factors may be important. This review will ... Cited by 84 - Related articles - BL Direct - All 6 versions
- ►physiology.org CK Roberts, D Won, S Pruthi, S Kurtovic, … - Journal of Applied …, 2006 - Am Physiological Soc The present study was designed to examine the effects of lifestyle modification on key contributing
factors to atherogenesis, including oxidative stress, inflammation, chemotaxis, and cell
adhesion. Obese men (n = 31), 15 of whom had metabolic syndrome, were placed on a ... Cited by 72 - Related articles - BL Direct - All 5 versions
- ►onlinejacc.org AA Meyer, G Kundt, U Lenschow, P Schuff-Werner, … - Journal of the American …, 2006 - Elsevier The present study aimed to assess the effect of a 6-month exercise program in obese children
on flow-mediated vasodilation (FMD) carotid intima-media thickness (IMT) and cardiovascular
risk factors (RF). ... Childhood obesity contributes to adult obesity and subsequent ... Cited by 66 - Related articles - BL Direct - All 20 versions
PJ Grant - Journal of internal medicine, 2007 - pt.wkhealth.com Diabetes mellitus (DM) is characterized by fasting hyperglycaemia and a high risk of atherothrombotic
disorders affecting the coronary, cerebral and peripheral arterial trees. The risk of myocardial
infarction (MI) is 3-5 fold higher in Type 2 DM and a DM subject with no history of MI has ... Cited by 58 - Related articles - BL Direct - All 6 versions
- ►endojournals.org AE Caballero, A Delgado, CA Aguilar-Salinas, … - Journal of Clinical …, 2004 - Endocrine Soc The effect of metformin (1000 mg twice a day) on markers of endothelial activation,
inflammation, and coagulation was investigated in subjects with impaired glucose tolerance
(IGT) in a 16-wk, randomized, placebo-controlled, double-blind study. Soluble ... Cited by 53 - Related articles - BL Direct - All 7 versions
