T Haak, A Tiengo, E Draeger, M Suntum, W … - Diabetes Obesity and …, 2005 - fe-inzichten.nl Aim: The aim of this study was to compare the efficacy and safety of a basal-bolus insulin regimen
comprising either insulin detemir or neural protamine hagedorn (NPH) insulin in combination
with mealtime insulin aspart in patients with type 2 diabetes. Methods: This was a ... Cited by 193 - Related articles - View as HTML - All 5 versions
MY Donath, PA Halban - Diabetologia, 2004 - Springer Increasing evidence indicates that decreased functional beta-cell mass is the hallmark of both
Type 1 and Type 2 diabetes. This underlies the absolute or relative insu- lin insufficiency in both
conditions. In this For Debate, we consider the possible mechanisms responsible for beta- ... Cited by 123 - Related articles - BL Direct - All 6 versions
- ►endojournals.org BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc There is a progressive deterioration in ß-cell function and mass in type 2 diabetics. It was found
that islet function was about 50% of normal at the time of diagnosis, and a reduction in ß-cell
mass of about 60% was shown at necropsy. The reduction of ß-cell mass is attributable to ... Cited by 105 - Related articles - BL Direct - All 7 versions
MY Donath, JA Ehses, K Maedler, DM Schumann, H … - Diabetes, 2005 - Am Diabetes Assoc A decrease in the number of functional insulin-producing β-cells contributes to the pathophysiology
of type 2 diabetes. Opinions diverge regarding the relative contribution of a decrease in β-cell
mass versus an intrinsic defect in the secretory machinery. Here we review the evidence ... Cited by 86 - Related articles - BL Direct - All 6 versions
- ►endojournals.org K Maedler, RD Carr, D Bosco, RA Zuellig, T … - Journal of Clinical …, 2005 - Endocrine Soc Loss of ß-cell mass and function raises a concern regarding the application of sulfonylureas
for the treatment of type 2 diabetes because previous studies have shown that agents that cause
closure of inwardly rectifying K + sulfonylurea receptor subtype of ATP-sensitive ... Cited by 79 - Related articles - All 6 versions
T Nakamura, T Matsuda, Y Kawagoe, H Ogawa, Y … - Metabolism, 2004 - Elsevier Atherosclerosis is the major cause of morbidity and mortality in patients with type 2 diabetes,
and pioglitazone has been reported to have anti-inflammatory and potential antiatherogenic
effects. The aim of the present study was to determine whether pioglitazone, ... Cited by 75 - Related articles - All 8 versions
RA DeFronzo, RM Bergenstal, WT Cefalu, J Pullman, S … - Diabetes Care, 2005 - cat.inist.fr OBJECTIVE- Effective type 2 diabetes management requires prompt intervention if glycemic
control is not achieved by nonpharmacological means. This study investigates whether inhaled
insulin(INH; Exubera) can achieve target glycemic control in patients failing on diet and ... Cited by 73 - Related articles - BL Direct - All 5 versions
LE Fridlyand, LH Philipson - Diabetes, 2004 - Am Diabetes Assoc Glucose-dependent insulin secretion (GDIS), reactive oxygen species (ROS) production, and
oxidative stress in pancreatic β-cells may be tightly linked processes. Here we suggest that the
same pathways used in the activation of GDIS (increased glycolytic flux, ATP-to-ADP ... Cited by 54 - Related articles - BL Direct - All 5 versions
- ►dminsulinpump.co.kr [PDF] J Weng, Y Li, W Xu, L Shi, Q Zhang, D Zhu, Y Hu, Z … - The Lancet, 2008 - Elsevier 382 patients, aged 25–70 years, were enrolled from nine centres in China between
September, 2004, and October, 2006. The patients, with fasting plasma glucose of 7·0–16·7
mmol/L, were randomly assigned to therapy with insulin (CSII or MDI) or oral ... Cited by 52 - Related articles - All 25 versions
G Stenström, A Gottsäter, E Bakhtadze, B Berger, G … - Diabetes, 2005 - Am Diabetes Assoc Latent autoimmune diabetes in adults (LADA) is a disorder in which, despite the presence of
islet antibodies at diagnosis of diabetes, the progression of autoimmune β-cell failure is
slow. LADA patients are therefore not insulin requiring, at least during the first 6 months ... Cited by 35 - Related articles - BL Direct - All 4 versions
