- ►cell.com LKM Shoda, DL Young, S Ramanujan, CC … - Immunity, 2005 - Elsevier Type 1 diabetes (T1D) animal models such as the nonobese diabetic (NOD) mouse
have improved our understanding of disease pathophysiology, but many candidate
therapeutics identified therein have failed to prevent/cure human disease. ... Cited by 94 - Related articles - All 6 versions
T Staeva-Vieira, M Peakman, M Von Herrath - Clinical and Experimental Immunology, 2007 - pubmedcentral.nih.gov Type 1 diabetes (T1D) is often considered the prototype organ-specific
autoimmune disease in clinical immunology circles. The key disease features −
precise destruction of a single endocrine cell type occurring on a distinct ... Cited by 47 - Related articles - BL Direct - All 5 versions
KS Goudy, R Tisch - International reviews of immunology, 2005 - informahealthcare.com A major effort has been on-going to develop immunotherapies to prevent and/or
treat type 1 diabetes (T1D). This autoimmune disease is characterized by the
selective loss of the insulin-producing β cells via the cumulative effects ... Cited by 25 - Related articles - BL Direct - All 5 versions
S You, N Thieblemont, MA Alyanakian, JF … - Immunol Rev, 2006 - interscience.wiley.com Summary: It is now well‐established that CD4 + regulatory T cells are
instrumental in controlling immune responses both to self‐antigens and to
non‐self‐antigens. However, the precise modalities involved in their ... Cited by 25 - Related articles - BL Direct - All 5 versions
- ►nih.gov D Bresson, M Von Herrath - Autoimmunity reviews, 2007 - Elsevier Every year, thirty thousand people worldwide are diagnosed with type 1 diabetes
mellitus (T1DM). T1DM, also called autoimmune diabetes, is a multifactorial
disease affecting predisposed individuals and involving genetic ... Cited by 20 - Related articles - All 3 versions
MJ Haller, PA Gottlieb, DA Schatz - Current Opinion in Endocrinology, Diabetes and …, 2007 - journals.lww.com Purpose of review: Type 1 diabetes (T1D) is characterized by autoimmune-mediated
destruction of pancreatic β cells culminating in absolute insulin deficiency.
Despite enhanced knowledge of the natural history of type 1 diabetes we ... Cited by 10 - Related articles - BL Direct - All 2 versions
RS McIntyre, JK Soczynska, GF Lewis, GM … - Expert Opin. Pharmacother., 2006 - Informa Pharma Science The objective of this paper is to synthesise extant studies describing the
neurotherapeutic effects of antidiabetic agents in neuropsychiatric disorders.
The authors conducted a MedLine search of all English-language articles ... Cited by 7 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org P Narendran, E Estella, S Fourlanos - Qjm, 2005 - Oxford Univ Press There are over one million islets in a healthy adult pancreas. They make up 1%
of the total pancreatic volume, weigh about 1 g, and contain about 1 mg of
insulin. 4 Histological analysis of the pancreas from patients with type 1 ... Cited by 7 - Related articles - BL Direct - All 7 versions
- ►endojournals.org SE Fineberg, TT Kawabata, D Finco-Kent, RJ … - Endocrine Reviews, 2007 - Endocrine Soc Regardless of purity and origin, therapeutic insulins continue to be immunogenic
in humans. However, severe immunological complications occur rarely, and less
severe events affect a small minority of patients. Insulin autoantibodies ... Cited by 6 - Related articles - BL Direct - All 3 versions
LC Harrison - Immunology and Cell Biology, 2008 - nature.com Immune tolerance to self-antigens is physiological. Given a repertoire of
self-reactive, potentially pathogenic lymphocytes, therapeutic options to
diminish autoimmune disease risk include deletion, reduced activation or ... Cited by 6 - Related articles - All 4 versions
