- ►nih.gov RK Vikramadithyan, Y Hu, HL Noh, CP Liang, … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Direct evidence that hyperglycemia, rather than concomitant increases in known
risk factors, induces atherosclerosis is lacking. Most diabetic mice do not
exhibit a higher degree of atherosclerosis unless the development of ... Cited by 53 - Related articles - BL Direct - All 13 versions
- ►diabetesjournals.org N Hotta, Y Akanuma, R Kawamori, K Matsuoka, … - Diabetes Care, 2006 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Subjects with diabetic neuropathy, median motor
nerve conduction velocity (MNCV) ≥40 m/s, and HbA 1c ≤9% were enrolled in
this open-label, multicenter study and randomized to 150 mg/day epalrestat ... Cited by 46 - Related articles - BL Direct - All 5 versions
- Free from Publisher V Bril, RA Buchanan - Diabetes Care, 2006 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Patients with mild to moderate DSP, as determined
by the presence of sural nerve responses, were enrolled in a double-blind,
placebo-controlled biopsy trial and randomized to placebo or 5 or 20 mg/day ... Cited by 44 - Related articles - BL Direct - All 6 versions
R Pop-Busui, A Sima, M Stevens - Diabetes/Metabolism Reviews - interscience.wiley.com This review will focus on the impact of hyperglycemia-induced oxidative stress
in the development of diabetes-related neural dysfunction. Oxidative stress
occurs when the balance between the production of reactive oxygen species ... Cited by 42 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org W Sun, PJ Oates, JB Coutcher, C … - Diabetes, 2006 - Am Diabetes Assoc Previously studied inhibitors of aldose reductase were largely from two chemical
classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its
own drawbacks regarding selectivity, in vivo potency, and human safety; as ... Cited by 38 - Related articles - BL Direct - All 7 versions
- Free from Publisher K Ekberg, T Brismar, BL Johansson, P … - Diabetes Care, 2007 - Am Diabetes Assoc RESULTS—The age of the 139 patients who completed the protocol was 44.2 ± 0.6
(mean ± SE) years and their duration of diabetes was 30.6 ± 0.8 years.
Clinical neurological impairment (NIA) (score >7 points) of the lower ... Cited by 35 - Related articles - BL Direct - All 5 versions
PJ Oates - Current drug targets, 2008 - ingentaconnect.com Abstract: Aldose reductase (AR) enzymatically transforms cytosolic glucose into
sorbitol, a molecule that poorly pene- trates cell membranes and is sometimes
slowly metabolized. Hyperglycemia can cause intracellular accumulation of ... Cited by 26 - Related articles - BL Direct - All 3 versions
- ►shouxi.net W Sun, C Gerhardinger, Z Dagher, T Hoehn, … - Diabetes, 2005 - Am Diabetes Assoc The prevention of diabetic retinopathy requires drugs that leverage the benefits
of glycemic control without adding the burden of side effects. Aspirin at
dosages of 1–1.5 g/day has prevented manifestations of diabetic retinal ... Cited by 24 - Related articles - BL Direct - All 6 versions
A Vinik, J Ullal, HK Parson, CM Casellini - Nature Clinical Practice Endocrinology & Metabolism, 2006 - nature.com Dr Aaron Vinik is a Professor of Internal Medicine Pathology, Neurobiology and
the Director of Research at the Leonard Strelitz Diabetes Institutes, Eastern
Virginia Medical School, Norfolk, VA, USA. He is a physician scientist in ... Cited by 23 - Related articles - BL Direct - All 4 versions
KH Gabbay - Current Diabetes Reports, 2004 - Springer Introduction The major complications associated with long-term diabetes mellitus
are retinopathy, nephropathy, neuropathy, cata- racts, and micro- and
macrovascular disease. The devel- opment of complications is a long-term ... Cited by 16 - Related articles - All 3 versions
