- ►nih.gov KE Wellen, GS Hotamisligil - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Over the last decade, an abundance of evidence has emerged demonstrating a close
link between metabolism and immunity. It is now clear that obesity is associated
with a state of chronic low-level inflammation. In this article, we discuss ... Cited by 777 - Related articles - All 15 versions
- ►nih.gov SP Weisberg, D Hunter, R Huber, J Lemieux, S … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig The CC motif chemokine receptor–2 (CCR2) regulates monocyte and macrophage
recruitment and is necessary for macrophage-dependent inflammatory responses and
the development of atherosclerosis. Although adipose tissue expression and ... Cited by 315 - Related articles - BL Direct - All 14 versions
- ►sld.cu [PDF] Å Sjöholm, T Nyström - The Lancet, 2005 - Elsevier Type 2 diabetes and attendant cardiovascular morbidity are becoming major health
concerns globally. Obesity-related type 2 diabetes is rapidly rising in
prevalence, probably largely because of increased longevity and sedentary ... Cited by 169 - Related articles - All 8 versions
- ►onlinejacc.org PR Moreno, V Fuster - Journal of the American College of Cardiology, 2004 - Elsevier Diabetes mellitus is increasing worldwide, resulting from the interaction of
obesity, inflammation, and hyperglycemia. Activated immunity and cytokine
production lead to insulin resistance and other components of the metabolic ... Cited by 166 - Related articles - All 15 versions
H Kolb, T Mandrup-Poulsen - Diabetologia, 2005 - Springer Abstract Subclinical, low-grade systemic inflammation has been observed in
patients with type 2 diabetes and in those at increased risk of the disease.
This may be more than an epiphenomenon. Alleles of genes encoding immune/ ... Cited by 116 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org GS Hotamisligil - Diabetes, 2005 - Am Diabetes Assoc Metabolic and immune systems are the most fundamental requirements for survival,
and many metabolic and immune response pathways or nutrient- and
pathogen-sensing systems have been evolutionarily highly conserved. ... Cited by 104 - Related articles - BL Direct - All 7 versions
- ►shouxi.net PA Tataranni, E Ortega - Diabetes, 2005 - Am Diabetes Assoc There is growing support for the hypothesis that obesity is an inflammatory
condition leading to chronic activation of the innate immune system, which
ultimately causes progressive impairment of glucose tolerance. Experimental ... Cited by 102 - Related articles - All 9 versions
- ►tau.ac.il [PDF] S Melamed, A Shirom, S Toker, S Berliner, I … - Psychological Bulletin, 2006 - psycnet.apa.org Burnout is characterized by emotional exhaustion, physical fatigue, and
cognitive weariness, resulting from prolonged exposure to work-related stress.
The authors review the accumulated evidence suggesting that burnout and the ... Cited by 99 - Related articles - BL Direct - All 13 versions
- ►endojournals.org BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc There is a progressive deterioration in ß-cell function and mass in type 2
diabetics. It was found that islet function was about 50% of normal at the time
of diagnosis, and a reduction in ß-cell mass of about 60% was shown at ... Cited by 100 - Related articles - BL Direct - All 7 versions
- ►ajcn.org MB Schulze, K Hoffmann, JAE Manson, WC … - American Journal of Clinical Nutrition, 2005 - Am Soc Nutrition 2 Supported by research grants (CA50385, CA87969, HL60712, and DK58845) from the
National Institutes of Health. MBS is supported by a grant from the Deutsche
Krebshilfe. JBM is supported in part by an American Diabetes Association ... Cited by 86 - Related articles - BL Direct - All 8 versions
