- ►nih.gov DJ Drucker - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The gastrointestinal tract has a crucial role in the control of energy
homeostasis through its role in the digestion, absorption, and assimilation of
ingested nutrients. Furthermore, signals from the gastrointestinal tract ... Cited by 87 - Related articles - BL Direct - All 11 versions
MC Riddle, DJ Drucker - Diabetes Care, 2006 - Am Diabetes Assoc Current therapies for type 2 diabetes are frequently associated with inadequate
control of postprandial hyperglycemia, weight gain, and, in the case of oral
agents, loss of efficacy over time. A better understanding of physiological ... Cited by 72 - Related articles - BL Direct - All 10 versions
BE Dunning, JE Foley, B Ahren - Diabetologia, 2005 - Springer Abstract Although there is abundant evidence that hyper- glucagonaemia plays a
key role in the development of hy- perglycaemia in type 2 diabetes, efforts to
understand and correct this abnormality have been overshadowed by the ... Cited by 70 - Related articles - BL Direct - All 3 versions
- ►pasteur.ac.ir [PDF] LL Nielsen - Drug discovery today, 2005 - Elsevier Incretin mimetics are a new class of pharmacological agents with multiple
antihyperglycemic actions that mimic the actions of incretin hormones such as
glucagon-like peptide (GLP)-1. Dipeptidyl peptidase (DPP-IV) inhibitors ... Cited by 45 - Related articles - All 7 versions
A Patriti, E Facchiano, C Annetti, MC Aisa, F … - Obesity surgery, 2005 - Springer Background: Surgical operations which shorten the intestinal tract between the
stomach and the terminal ileum result in an early improvement in type 2 dia-
betes, and one possible explanation is the arrival of undigested food in ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►physiology.org EM Sinclair, DJ Drucker - Physiology, 2005 - Am Physiological Soc The proglucagon-derived peptides (PGDPs) are encoded by a single mammalian
proglucagon gene. Tissue-specific posttranslational processing mediated by
prohormone convertase (PC) enzymes liberates these peptide hormones in a ... Cited by 30 - Related articles - All 4 versions
JL Estall, DJ Drucker - Current pharmaceutical design, 2006 - ingentaconnect.com Abstract: Glucagon and the glucagon-like peptides are derived from a common
proglucagon precursor, and regulate en- ergy homeostasis through interaction
with a family of distinct G protein coupled receptors. Three ... Cited by 26 - Related articles - BL Direct - All 5 versions
- ►qub.ac.uk [PDF] BD Green, PR Flatt - Best Practice & Research Clinical Endocrinology & …, 2007 - Elsevier The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP) are physiological gut peptides with
insulin-releasing and extrapancreatic glucoregulatory actions. Incretin ... Cited by 29 - Related articles - All 17 versions
JF Todd, SR Bloom - Diabetic Medicine, 2007 - peoriaendocrine.com Glucagon-like peptide-1 (7-36) amide (GLP-1) is a gut hormone, released post-
prandially, which stimulates insulin secretion and insulin gene expression as
well as pancreatic B-cell growth. Together with glucose-dependent insulino- ... Cited by 24 - Related articles - View as HTML - BL Direct - All 6 versions
- ►oxfordjournals.org GG Gosman, HI Katcher, RS Legro - Human reproduction update, 2006 - ESHRE Reproductive function declines at both extremes of human energy balance. The
relationship between obesity and reproductive function is complex and
incompletely understood. The literature has established the negative impact ... Cited by 25 - Related articles - BL Direct - All 8 versions
