RI Misbin - Diabetes Care, 2004 - Am Diabetes Assoc Metformin is the only biguanide that is available in the US Another biguanide, phenformin, had
been used since the 1950s, but was declared an “imminent hazard” in 1976 because of lactic
acidosis (1). At the time of its removal from the market, there had been 306 documented ... Cited by 60 - Related articles - All 5 versions
A Holstein, M Stumvoll - Diabetologia, 2005 - Springer Abstract Metformin is an effective anti-hyperglycaemic and cardioprotective agent, but a long
list of contraindi- cations precludes millions of patients with type 2 diabetes from using it. This
is largely due to the historical expe- rience of lactic acidosis with phenformin, despite the ... Cited by 61 - Related articles - BL Direct - All 3 versions
M Freemark - Diabetes Care, 2007 - care.diabetesjournals.org.p. … Forty-five years after an amphetamine was approved for the treatment of obesity in adults, an
expert in the field characterized a new therapeutic formulation as being effective and
long-lasting, posing “little risk” (1). Four years later, others (2) “confirmed the weight- ... Cited by 21 - Related articles - All 9 versions
- ►geyseco.info [PDF] E Selvin, S Bolen, HC Yeh, C Wiley, LM Wilson … - Archives of Internal …, 2008 - Am Med Assoc Methods We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled
Trials, from inception through January 19, 2006. Forty publications of controlled trials that reported
information on cardiovascular events (primarily myocardial infarction and stroke) met our ... Cited by 23 - Related articles - All 5 versions
- ►dvdres.com [PDF] JHB Scarpello, H Howlett - Diabetes & Vascular Disease Research, 2008 - dvr.sagepub.com Abstract M etformin is now established as a first-line antidiabetic therapy for the management
of type 2 diabetes. Its early use in treatment algo- rithms is supported by lack of weight gain, low
risk of hypoglycaemia and its mode of action to counter insulin resistance. The drug's anti- ... Cited by 18 - Related articles - All 8 versions
O Pinhas-Hamiel, P Zeitler - Advances in pediatrics, 2005 - Elsevier Type 2 diabetes mellitus (T2DM) has dramatically increased throughout the world in many ethnic
groups and among people with diverse social and economic backgrounds. This increase has
also affected the young, such that over the last decade, the increase in the number of ... Cited by 9 - Related articles - All 15 versions
O Pinhas-Hamiel, P Zeitler - Pediatric Diabetes, 2007 - interscience.wiley.com Abstract: Type 2 diabetes mellitus (T2DM) has dramatically increased throughout the world in
many ethnic groups and among people with diverse social and economic backgrounds. This
increase has also affected the young such that over the past decade, the increase in the ... Cited by 9 - Related articles - BL Direct - All 3 versions
JCN Chan, C Deerochanawong, AS Shera, KH … - Diabetes research and …, 2007 - Elsevier Increases in the prevalence of type 2 diabetes of 30–60% will occur in many Asian-Pacific countries
by 2025, driven by urbanisation, sedentary habits and energy-rich diets. Obesity, insulin
resistance, metabolic syndrome and diabetes are closely interrelated. Optimal control of ... Cited by 7 - Related articles - All 15 versions
RI Misbin - Diabetes care, 2005 - Am Diabetes Assoc Problems had been festering at the Food and Drug Administration (FDA) for years (1,2). In
2004, the abscess finally broke. First came the recognition that widely used antidepressants
were associated with suicide in young patients, and then came the withdrawal of Vioxx. ... Cited by 7 - Related articles - BL Direct - All 5 versions
