- ►brain-treatments.net [PDF] RJ Shaw - Current opinion in cell biology, 2006 - Elsevier The first identified biochemical hallmark of tumor cells was a shift in glucose
metabolism from oxidative phosphorylation to aerobic glycolysis. We now know
that much of this metabolic conversion is controlled by specific ... Cited by 105 - Related articles - All 7 versions
H Motoshima, BJ Goldstein, M Igata, E Araki - The Journal of physiology, 2006 - Physiological Soc AMPK is a serine/threonine protein kinase, which serves as an energy sensor in
all eukaryotic cell types. Published studies indicate that AMPK activation
strongly suppresses cell proliferation in non-malignant cells as well as in ... Cited by 91 - Related articles - BL Direct - All 9 versions
M Zakikhani, R Dowling, IG Fantus, N … - Cancer Research, 2006 - AACR Metformin (1,1-dimethylbiguanide hydrochloride) is a biguanide commonly used in
the treatment of type 2 diabetes mellitus (1). It is frequently referred to as
an "insulin sensitizer" because in settings of insulin resistance and ... Cited by 75 - Related articles - BL Direct - All 7 versions
Z Gong, ML Neuhouser, PJ Goodman, D … - Cancer Epidemiology Biomarkers & Prevention, 2006 - AACR Many studies have examined the role of obesity in prostate cancer etiology, but
their results have been conflicting and inconclusive (1, 2). Most studies have
found no association between obesity and prostate cancer incidence (1, 3, ... Cited by 67 - Related articles - BL Direct - All 7 versions
M Buzzai, RG Jones, RK Amaravadi, JJ Lum, … - Cancer Research, 2007 - AACR Beyond the reported effects of metformin on insulin-responsive tissues, little
is known about the effects of metformin on other cell types. However, AMPK is a
intracellular fuel sensor that regulates cellular homeostasis in response ... Cited by 61 - Related articles - BL Direct - All 5 versions
- ►mcgill.ca [PDF] M Pollak - Nat Rev Cancer, 2008 - canadiancpd.medscape.com Insulin and insulin-like growth factors (IGFs) are well known as key regulators
of energy metabolism and growth. There is now considerable evidence that these
hormones and the signal transduction networks they regulate have important ... Cited by 46 - Related articles - All 10 versions
F Frasca, G Pandini, L Sciacca, V Pezzino, S … - Archives of physiology and biochemistry, 2008 - informahealthcare.com There is evidence, both in vitro and in vivo, that receptor tyrosine kinases
play a key role in the formation and progression of human cancer. In particular,
the insulin-like growth factor receptor (IGF-IR), a tyrosine kinase ... Cited by 33 - Related articles - BL Direct - All 6 versions
- ►easd.org [PDF] CJ Currie, CD Poole, EAM Gale - Diabetologia, 2009 - Springer Abstract Aims/hypothesis The risk of developing a range of solid tumours is
increased in type 2 diabetes, and may be influenced by glucose-lowering
therapies. We examined the risk of development of solid tumours in relation ... Cited by 34 - Related articles - All 9 versions
P Katajisto, T Vallenius, K Vaahtomeri, N … - BBA-Reviews on Cancer, 2007 - Elsevier Inactivating germline mutations in the LKB1 gene underlie Peutz–Jeghers
syndrome characterized by hamartomatous polyps and an elevated risk for cancer.
Recent studies suggest the involvement of LKB1 also in more common human ... Cited by 29 - Related articles - All 5 versions
WW Winder, DM Thomson - Cell Biochemistry and Biophysics, 2007 - Springer Abstract AMP-activated protein kinase (AMPK) is an energy sensing/signaling
protein that, when activated, increases ATP production by stimulating glucose
uptake and fatty acid oxidation while at the same time inhibiting ATP ¼ ... Cited by 24 - Related articles - BL Direct - All 3 versions
