- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the
pathogenesis of diabetes, contributing to pancreatic β-cell loss and insulin resistance. Components
of the unfolded protein response ... Cited by 93 - Related articles - BL Direct - All 5 versions
- ►biologists.org DA Cunha, P Hekerman, L Ladriere, A Bazarra- … - Journal of cell …, 2008 - jcs.biologists.org Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might contribute to β-cell loss
in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied here the
molecular mechanisms implicated in ... Cited by 23 - Related articles - All 5 versions
PJ Guillausseau, T Meas, M Virally, M Laloi-Michelin … - Diabetes and Metabolism, 2008 - Elsevier Type 2 diabetes mellitus is a multifactorial disease, due to decreased glucose peripheral uptake,
and increased hepatic glucose production, due to reduced both insulin secretion and insulin
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M Cnop - Biochemical Society Transactions, 2008 - biochemsoctrans.org The prevalence of Type 2 diabetes is increasing dramatically as a result of the obesity epidemic,
and poses a major health and socio-economic burden. Type 2 diabetes develops in individuals who fail
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J Garbarino, SL Sturley - Current Opinion in Clinical Nutrition & …, 2009 - journals.lww.com Recent findings: The relatively recent isolation of lipid acyltransferase genes from yeast to mice
and humans has resulted in a paradigm shift that now establishes all fatty acids as toxic, albeit in
tissue specific patterns and by ... Cited by 5 - Related articles - All 3 versions
AG Tabák, M Jokela, TN Akbaraly, EJ Brunner, M … - The Lancet, 2009 - Elsevier Multilevel models adjusted for age, sex, and ethnic origin confirmed that all metabolic measures
followed linear trends in the group of non-diabetics (10 989 measurements), except for insulin
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- ►diabetesjournals.org AMG Cali, CD Man, C Cobelli, J Dziura, A Seyal, M … - Diabetes Care, 2009 - Am Diabetes Assoc RESULTS—At baseline, all 60 subjects had NGT. Seventy-seven percent (46 subjects) maintained NGT
over the three testing periods (nonprogressors), whereas 23% (14 subjects) developed IGT over time
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SE Kahn, DB Carr, MV Faulenbach, KM … - Diabetes, Obesity and …, 2008 - interscience.wiley.com A characteristic and dominant feature of type 2 diabetes is a reduction in β-cell function that is
associated with a decrease in β-cell volume. A decline in the first-phase insulin response
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- ►diabetesjournals.org KM Utzschneider, RL Prigeon, MV Faulenbach, J … - Diabetes Care, 2009 - Am Diabetes Assoc RESULTS— I 0–30 / G 0–30 demonstrated a curvilinear relationship with 1/fasting insulin and
HOMA-S with a left and downward shift as glucose tolerance deteriorated. The confidence limits for
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- ►nih.gov G Coppola, D Marmolino, D Lu, Q Wang, M … - Human Molecular …, 2009 - Oxford Univ Press Friedreich's ataxia (FRDA), the most common inherited ataxia, is characterized by focal
neurodegeneration, diabetes mellitus and life-threatening cardiomyopathy. Frataxin, which is
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