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Cardiorenal protection with aliskiren, a direct renin inhibitor, in the ASPIRE …


HY Lee, BH Oh - Expert Review of Cardiovascular Therapy, 2009 - ingentaconnect.com
Aliskiren (Tekturna ® , Rasilez ® ) is the first in a new class of orally effective direct renin inhibitors
(DRIs). It binds to the active site of the renin molecule blocking angiotensinogen cleavage, thus
preventing the formation of angi- otensin I [1] . Initial results of clinical efficacy studies ...
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