JO Miners, DJ Birkett - British journal of clinical pharmacology, 1998 - pubmedcentral.nih.gov Accumulating evidence indicates that CYP2C9 ranks amongst the most important
drug metabolizing enzymes in humans. Substrates for CYP2C9 include fluoxetine,
losartan, phenytoin, tolbutamide, torsemide, S-warfarin, and numerous ... Cited by 455 - Related articles - BL Direct - All 8 versions
TH Sullivan-Klose, BI Ghanayem, DA Bell, ZY … - Pharmacogenetics and Genomics, 1996 - journals.lww.com Pharmacogenetics (1996) 6, 341-349 Original article The role of the
CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism* Theresa H.
Sullivan-Klose1,2, Burhan I. Ghanayem1, Douglas A. Bell1, Zhi-Yi Zhang3, ... Cited by 415 - Related articles - BL Direct - All 5 versions
JA Goldstein - British Journal of Clinical Pharmacology, 2001 - pubmedcentral.nih.gov The human CYP2Cs are an important subfamily of P450 enzymes that metabolize
approximately 20% of clinically used drugs. There are four members of the
subfamily, CYP2C8, CYP2C9, CYP2C19, and CYP2C18. Of these CYP2C8, CYP2C9, ... Cited by 316 - Related articles - BL Direct - All 10 versions
CR Lee, JA Goldstein, JA Pieper - Pharmacogenetics and Genomics, 2002 - journals.lww.com The discovery of six distinct polymorphisms in the genetic sequence encoding for
the cytochrome P450 2C9 (CYP2C9) protein has stimulated numerous investigations
in an attempt to characterize their population distribution and metabolic ... Cited by 307 - Related articles - BL Direct - All 8 versions
- ►ujaen.es [PDF] HG Xie, RB Kim, AJJ Wood, CM Stein - Annual Review of Pharmacology and Toxicology, 2001 - Annual Reviews ▪ Abstract Ethnicity is an important demographic variable contributing to
interindividual variability in drug metabolism and response. In this rapidly
expanding research area many genetic factors that account for the effects ... Cited by 289 - Related articles - BL Direct - All 9 versions
A Küpfer, R Preisig - European journal of clinical pharmacology, 1984 - Springer Summary. Inherited deficiency in mephenytoin hy- droxylation was observed in a
family study. It is im- portant that the propositus was of the extensive me-
tabolizer phenotype for the genetically controlled hydroxylation of ... Cited by 267 - Related articles - All 3 versions
- ►aspetjournals.org RS Obach - Drug Metabolism and Disposition, 1999 - ASPET Twenty-nine drugs of disparate structures and physicochemical properties were
used in an examination of the capability of human liver microsomal lability data
("in vitro T 1/2 " approach) to be useful in the prediction of human ... Cited by 263 - Related articles - BL Direct - All 8 versions
MV Relling, T Aoyama, FJ Gonzalez, UA … - Journal of Pharmacology and Experimental …, 1990 - ASPET ABBREVIATIONS: TB,tolbutamkle;MEPH, mephenytoin; LKM, liver-kidney-microsome;
Hplc, high-performance liquid chromatography. ... 0022-3565/90/2521
-0442$OO.0O/0 THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS ... Cited by 175 - Related articles - All 2 versions
ER Pearson, BJ Starkey, RJ Powell, FM … - The Lancet, 2003 - Elsevier Type 2 diabetes shows evidence of underlying heterogeneity. No studies have
assessed whether different causes for diabetes change the response to oral
hypoglycaemic therapy. In a few cases, patients with diabetes caused by ... Cited by 133 - Related articles - All 4 versions
