C Fleury, M Neverova, S Collins, S Raimbault … - Nature Genetics, 1997 - nature.com A mitochondrial protein called uncoupling protein (UCP1) plays an important role
in generating heat and burning calories by creating a pathway that allows
dissipation of the proton electrochemical gradient across the inner ... Cited by 1119 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] J Kopecky, G Clarke, S Enerbäck, B … - Journal of Clinical Investigation, 1995 - pubmedcentral.nih.gov The brown fat-specific mitochondrial uncoupling protein (UCP) provides a
mechanism for generating heat by uncou- pling respiration and oxidative
phosphorylation. It has been suggested that this system of thermogenesis ... Cited by 196 - Related articles - BL Direct - All 8 versions
- ►endojournals.org SO Rzonca, LJ Suva, D Gaddy, DC Montague, … - Endocrinology, 2004 - Endocrine Soc Rosiglitazone is an FDA-approved oral antidiabetic agent for the treatment of
type 2 diabetes. This compound improves insulin sensitivity through the
activation of the nuclear receptor, peroxisome proliferator-activated ... Cited by 186 - Related articles - BL Direct - All 7 versions
- ►nih.gov RS Surwit, S Wang, AE Petro, D Sanchis, S … - Proceedings of the National Academy of Sciences of …, 1998 - National Acad Sciences Uncoupling protein 2 (UCP2) maps to a region on distal mouse chromosome 7 that
has been linked to the phenotypes of obesity and type II diabetes. We recently
reported that UCP2 expression is increased by high fat feeding in adipose ... Cited by 172 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org LJ Ma, SL Mao, KL Taylor, T Kanjanabuch, … - Diabetes, 2004 - Am Diabetes Assoc Increased plasminogen activator inhibitor 1 (PAI-1) has been linked to not only
thrombosis and fibrosis but also to obesity and insulin resistance. Increased
PAI-1 levels have been presumed to be consequent to obesity. We ... Cited by 173 - Related articles - BL Direct - All 4 versions
L Makowski, JB Boord, K Maeda, VR Babaev, KT … - Nature Medicine, 2001 - nature.com The adipocyte fatty-acid−binding protein, aP2, has an important role in
regulating systemic insulin resistance and lipid metabolism. Here we demonstrate
that aP2 is also expressed in macrophages, has a significant role in their ... Cited by 174 - Related articles - BL Direct - All 4 versions
- ►endojournals.org JP Berger, AE Petro, KL Macnaul, LJ Kelly, … - Molecular Endocrinology, 2003 - Endocrine Soc Antidiabetic thiazolidinediones (TZDs) and non-TZD compounds have been shown to
serve as agonists of the peroxisome proliferator-activated receptor (PPAR ).
Here, we report the identification and characterization of a novel non-TZD ... Cited by 170 - Related articles - BL Direct - All 4 versions
- ►nih.gov L Abu-Elheiga, W Oh, P Kordari, SJ Wakil - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Malonyl-CoA, generated by acetyl-CoA carboxylases ACC1 and ACC2, is a key
metabolite in the control of fatty acid synthesis and oxidation in response to
dietary changes. ACC2 is associated to the mitochondria, and Acc2 -/- mice ... Cited by 158 - Related articles - BL Direct - All 12 versions
- ►pnas.org [PDF] CB Verchere, DA D'Alessio, RD Palmiter, GC … - Proceedings of the National Academy of Sciences, 1996 - National Acad Sciences Page 1. Proc. Natl. Acad. Sci. USA Vol. 93, pp. 3492-3496, April 1996 Medical Sciences
Islet amyloid formation associated with hyperglycemia in ... Cited by 134 - Related articles - All 8 versions
AA Butler, DL Marks, W Fan, CM Kuhn, M … - Nature Neuroscience, 2001 - nature.com In response to moderately increased dietary fat content, melanocortin-4
receptor-null mutant (MC4R -/- ) mice exhibit hyperphagia and accelerated weight
gain compared to wild-type mice. An increased feed efficiency (weight ... Cited by 129 - Related articles - BL Direct - All 3 versions
