M Krssak, K Falk Petersen, A Dresner, L … - Diabetologia, 1999 - Springer Skeletal muscle insulin resistance is a common fea- ture of obesity,
dyslipidaemia and arterial hyperten- sion, and it is an important predisposing
factor for Type II (non-insulin-dependent) diabetes mellitus and premature ... Cited by 556 - Related articles - BL Direct - All 6 versions
C Yu, Y Chen, GW Cline, D Zhang, H Zong, … - Journal of Biological Chemistry, 2002 - ASBMB Recent studies have demonstrated that fatty acids induce insulin resistance in
skeletal muscle by blocking insulin activation of insulin receptor substrate-1
(IRS-1)-associated phosphatidylinositol 3-kinase (PI3-kinase). To examine ... Cited by 530 - Related articles - BL Direct - All 8 versions
M Borkman, LH Storlien, DA Pan, AB Jenkins … - The New England journal of medicine, 1993 - nejm.highwire.org Results In the patients undergoing surgery, the fasting serum insulin
concentration (a measure of insulin resistance) was negatively correlated with
the percentage of individual long-chain polyunsaturated fatty acids in the ... Cited by 475 - Related articles - BL Direct - All 6 versions
E Giovannucci - Cancer Causes and Control, 1995 - Springer Some factors related to Westernization or industrialization increase risk of
colon cancer. It is believed widely that this increase in risk is related to the
direct effects of dietary fat and fiber in the colonic lumen. However, the ... Cited by 457 - Related articles - BL Direct - All 5 versions
ED Abel, O Peroni, JK Kim, YB Kim, O Boss… - Nature, 2001 - nature.com The earliest defect in developing type 2 diabetes is insulin resistance 1, 2 ,
characterized by decreased glucose transport and metabolism in muscle and
adipocytes 3, 4 . The glucose transporter GLUT4 mediates insulin-stimulated ... Cited by 434 - Related articles - BL Direct - All 7 versions
E Widen, M Lehto, T Kanninen, J Walston, AR … - The New England journal of medicine, 1995 - nejm.highwire.org Page 1. 348 THE NEW ENGLAND JOURNAL OF MEDICINE Aug. 10, 1995 ASSOCIATION
OF A POLYMORPHISM IN THE b 3 -ADRENERGIC–RECEPTOR GENE ... Cited by 424 - Related articles - BL Direct - All 6 versions
- ►nih.gov JK Kim, YJ Kim, JJ Fillmore, Y Chen, I Moore, … - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and
may involve fat-induced activation of a serine kinase cascade involving IKK-β.
To test this hypothesis, we first examined insulin action and signaling in ... Cited by 423 - Related articles - BL Direct - All 9 versions
PJ Randle - Diabetes Metabolism-Research and Reviews, 1998 - interscience.wiley.com Competition for respiration between substrates in animal tissues has been known
for at least 80 Years. The most important interaction, quantitatively is between
glucose and fatty acids. The starting point in 1963 for the so called ... Cited by 369 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] DE Kelley, LJ Mandarino - Diabetes, 2000 - Am Diabetes Assoc For many years, the Randle glucose fatty acid cycle has been invoked to explain
insulin resistance in skeletal muscle of patients with type 2 diabetes or
obesity. Increased fat oxidation was hypothesized to reduce glucose ... Cited by 360 - Related articles - BL Direct - All 4 versions
- ►endojournals.org MI Goran, GDC Ball, ML Cruz - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc Overweight/obesity continues to increase in children and adolescents, and annual
obesity-related hospital costs in 6–17 yr olds have reached $127 million per
year. Overweight children and adolescents are now being diagnosed with ... Cited by 304 - Related articles - BL Direct - All 5 versions
