- ►columbia.edu [PDF] KC Herold, W Hagopian, JA Auger, E … - New England Journal …, 2002 - content.nejm.org Results Treatment with the monoclonal antibody maintained or improved insulin production after
one year in 9 of the 12 patients in the treatment group, whereas only 2 of the 12 controls had
a sustained response (P=0.01). The treatment effect on insulin responses lasted for at ... Cited by 474 - Related articles - BL Direct - All 11 versions
L Chatenoud, E Thervet, J Primo, JF … - Proc Natl Acad Sci …, 1994 - National Acad Sciences Institut National de la Sant6 et de la Recherche M6dicale U 25, H6pital Necker, 161 Rue de
Sevres, 75015 Paris, France Communicated by N. Le Douarin, August 23, 1993 ... ABSTRACT
Anti-CD3 monoclonal antibodies suppress immune responses by transient T-cell ... Cited by 295 - Related articles - BL Direct - All 10 versions
KC Herold, SE Gitelman, U Masharani, W Hagopian, B … - Diabetes, 2005 - Am Diabetes Assoc Despite advances in understanding autoimmune diabetes in animal models, there has been
little progress in altering the natural course of the human disease, which involves progression
to insulin deficiency. Studies with immunosuppressive agents have shown short-term ... Cited by 168 - Related articles - All 4 versions
- ►nih.gov KC Herold, JB Burton, F Francois, E … - Journal of clinical …, 2003 - Am Soc Clin Investig Dimeric Fc receptor (FcR) nonbinding anti-CD3 antibodies have been developed to minimize
toxicities associated with classical anti-CD3 monoclonal antibodies (eg, OKT3). Studies with
murine analogs of non-FcR–binding antibodies have shown reduced mitogenicity ... Cited by 120 - Related articles - BL Direct - All 8 versions
Q Tang, JA Bluestone - Immunological reviews, 2006 - interscience.wiley.com Summary: Endowed with the ability to actively suppress an immune response, regulatory T cells
(Tregs) hold the promise of halting ongoing pathogenic autoimmunity and restoring self-tolerance
in patients suffering from autoimmune diseases. Through many in vitro and in vivo ... Cited by 117 - Related articles - BL Direct - All 5 versions
S Casares, A Hurtado, RC McEvoy, A Sarukhan, H … - Nature Immunology, 2002 - nature.com Type 1 diabetes is an organ-specific autoimmune disease that is mediated by autoreactive T
cells. We show here that administration of a soluble dimeric peptide−major histocompatibility
complex (pMHC) class II chimera (DEF) to prediabetic double-transgenic mice prevents ... Cited by 63 - Related articles - BL Direct - All 3 versions
H Ochi, M Abraham, H Ishikawa, D Frenkel, K Yang, AS … - Nat Med, 2006 - 140.116.93.232 A major goal of immunotherapy for autoimmune diseases and transplantation is induction of
regulatory T cells that mediate immunologic tolerance. The mucosal immune system is
unique, as tolerance is preferentially induced after exposure to antigen, and induction of ... Cited by 58 - Related articles - View as HTML - BL Direct - All 9 versions
- ►jimmunol.org EL Masteller, MR Warner, W Ferlin, V … - The Journal of …, 2003 - Am Assoc Immnol Type 1 diabetes is an autoimmune disorder caused by autoreactive T cells that mediate destruction
of insulin-producing cells of the pancreas. Studies have shown that T cell tolerance can be restored
by inducing a partial or altered signal through the TCR. To investigate the potential of ... Cited by 54 - Related articles - BL Direct - All 3 versions
- ►endojournals.org RH Slover, GS Eisenbarth - Endocrine reviews, 1997 - Endocrine Soc The development of type I diabetes has been divided into a series of stages (8): 1) genetic
susceptibility; 2) "triggering"; 3) active autoimmunity often associated with the presence of
autoantibodies; 4) loss of ß-cell function as determined by intravenous glucose tolerance ... Cited by 50 - Related articles - BL Direct - All 4 versions
- ►archives-ouvertes.fr [PDF] R Mallone, GT Nepom - Clinical Immunology, 2004 - Elsevier Selective expansion and activation of a very small number of antigen-specific CD4 + T cells is
a remarkable and essential property of the adaptive immune response. Antigen-specific T cells
were until recently identified only indirectly by functional assays, such as antigen-induced ... Cited by 44 - Related articles - All 7 versions
