- ►diabetesjournals.org N Pørksen, M Hollingdal, C Juhl, P Butler, JD … - Diabetes, 2002 - Am Diabetes Assoc Insulin concentrations oscillate at a periodicity of 5–15 min per oscillation.
These oscillations are due to coordinate insulin secretory bursts, from millions
of islets. The generation of common secretory bursts requires strong within- ... Cited by 70 - Related articles - BL Direct - All 4 versions
N Pørksen - Diabetologia, 2002 - Springer In 1922, Karen Hansen [1] measured two series of blood glucose concentrations
and reported oscilla- tions in the peripheral concentrations of this sub-
strate, results which were validated by simultaneous sampling from two ... Cited by 64 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org R Ritzel, M Schulte, N Pørksen, MS Nauck, … - Diabetes, 2001 - Am Diabetes Assoc The insulinotropic gut hormone glucagon-like peptide (GLP)-1 increases secretory
burst mass and the amplitude of pulsatile insulin secretion in healthy
volunteers without affecting burst frequency. Effects of GLP-1 on secretory ... Cited by 42 - Related articles - BL Direct - All 4 versions
P Bergsten, NN Foundation, FE Foundation - Diabetes/Metabolism Reviews - interscience.wiley.com Plasma insulin displays 5-10 min oscillations. In Type 2 diabetes the regularity
of the oscillations disappears, which may lead to insulin receptor
down-regulation and glucose intolerance and explain why pulsatile delivery ... Cited by 38 - Related articles - BL Direct - All 4 versions
KS Polonsky, J Sturis, E Van Cauter - Hormone research, 2000 - content.karger.com In this article, recent experiments are reviewed which have addressed the role
of oscillatory insulin secretion in the pathophysiology of glucose intolerance
and diabetes. The ultradian oscillations of insulin secretion appear to be ... Cited by 38 - Related articles - BL Direct - All 5 versions
- ►escholarship.org JJ Meier, JD Veldhuis, PC Butler - Diabetes, 2005 - Am Diabetes Assoc In health, insulin is secreted in discrete pulses into the portal vein, and the
regulation of the rate of insulin secretion is accomplished by modulation of
insulin pulse mass. Several lines of evidence suggest that the pattern of ... Cited by 35 - Related articles - All 8 versions
- ►ucla.edu [PDF] JJ MEIER, A BHUSHAN, PC BUTLER - Pediatric research, 2006 - journals.lww.com Both type 1 and type 2 diabetes are characterized by a marked deficit in
beta-cell mass causing insufficient insulin secretion. Beta-cell replacement
strategies may eventually provide a cure for diabetes. Current therapeutic ... Cited by 32 - Related articles - BL Direct - All 7 versions
- ►escholarship.org JJ Meier, LL Kjems, JD Veldhuis, P Lefèbvre, … - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by an ∼60% loss of β-cell mass, a marked
defect in postprandial insulin secretion, and a failure to suppress postprandial
glucagon concentrations. It is possible that postprandial hyperglucagonemia ... Cited by 27 - Related articles - BL Direct - All 9 versions
LJ Fischer, MA Wagner, BV Madhukar - Toxicology and applied pharmacology, 1999 - Elsevier Polychlorinated biphenyls (PCBs) are environmental contaminants that induce
release of insulin in rat insulinoma cells, RINm5F (Fischer et al., Life Sci.
(1996) 59, 2041–2049). In the present study the mechanisms of this effect ... Cited by 22 - Related articles - BL Direct - All 6 versions
- ►physiology.org N Porksen, C Juhl, M Hollingdal, SM Pincus, J … - American Journal of Physiology- Endocrinology And …, 2000 - Am Physiological Soc Insulin is largely secreted as serial secretory bursts superimposed on basal
release, insulin secretion is regulated through changes of pulse mass and
frequency, and the insulin release pattern affects insulin action. ... Cited by 21 - Related articles - BL Direct - All 3 versions
