WH Gispen, GJ Biessels - Trends in Neurosciences, 2000 - Elsevier Diabetes mellitus is associated with cognitive deficits and an increased risk of dementia, particularly
in the elderly. These deficits are paralleled by neurophysiological and structural changes in the
brain. In animal models of diabetes, impairments of spatial learning occur in association ... Cited by 242 - Related articles - All 10 versions
GJ Biessels, S Staekenborg, E Brunner, C Brayne, P … - Lancet Neurology, 2006 - Elsevier The relation between diabetes and major types of dementia is controversial. This systematic
review examines the incidence of dementia in people with diabetes mellitus. We identified 14
eligible longitudinal population-based studies of variable methodological quality. The ... Cited by 156 - Related articles - All 10 versions
GJ Biessels, A Kamal, IJA Urban, BM Spruijt, DW … - Brain research, 1998 - Elsevier Streptozotocin-diabetic rats express deficits in water maze learning and hippocampal synaptic
plasticity. The present study examined whether these deficits could be prevented and/or reversed
with insulin treatment. In addition, the water maze learning deficit in diabetic rats was ... Cited by 132 - Related articles - All 6 versions
WQ Zhao, DL Alkon - Molecular and cellular endocrinology, 2001 - Elsevier As one of the most extensively studied protein hormones, insulin and its receptor have been
known to play key roles in a variety of important biological functions. Until recent years, the functions
of insulin and insulin receptor (IR) in the central nervous system (CNS) have largely ... Cited by 119 - Related articles - All 5 versions
CR Park - Neuroscience and biobehavioral reviews, 2001 - Elsevier Evidence has been accumulating recently that the hormone insulin may modulate cognitive activity
by acting in the central nervous system. Initially derived from the observation that insulin and
insulin receptors are found in specific brain areas, this evidence also includes cognitive ... Cited by 105 - Related articles - BL Direct - All 8 versions
ZG Li, W Zhang, G Grunberger, AAF Sima - Brain research, 2002 - Elsevier Duration-related cognitive impairment is an increasingly recognized complication of type 1
diabetes. To explore potential underlying mechanisms, we examined hippocampal abnormalities
in the spontaneously type 1 diabetic BB/W rat. As a functional assay of cognition, the ... Cited by 102 - Related articles - All 4 versions
WQ Zhao, H Chen, MJ Quon, DL Alkon - European journal of pharmacology, 2004 - Elsevier Insulin is best known for its action on peripheral insulin target tissues such as the adipocyte,
muscle and liver to regulate glucose homeostasis. In the central nervous system (CNS), insulin
and the insulin receptor are found in specific brain regions where they show evidence of ... Cited by 87 - Related articles - All 5 versions
- ►sc.edu [PDF] BS McEwen, LP Reagan - European journal of pharmacology, 2004 - Elsevier The family of facilitative glucose transporter (GLUT) proteins is responsible for the entry of glucose
into cells throughout the periphery and the brain. The expression, regulation and activity of GLUTs
play an essential role in neuronal homeostasis, since glucose represents the primary ... Cited by 85 - Related articles - All 5 versions
- ►jneurosci.org LJ Shanley, AJ Irving, J Harvey - Journal of Neuroscience, 2001 - Soc Neuroscience The obese gene product leptin is an important signaling protein that regulates food intake and
body weight via activation of the hypothalamic leptin receptor (Ob-Rb; Jacob et al., 1997 ).
However, there is growing evidence that Ob-Rb is also expressed in CNS regions, not ... Cited by 83 - Related articles - All 5 versions
A Kamal, GJ Biessels, SEJ Duis, WH Gispen - Diabetologia, 2000 - Springer Aims/hypothesis. Diabetes mellitus leads to function- al and structural changes in the brain which
appear to be most pronounced in the elderly. Because the pathogenesis of brain ageing and
that of diabetic complications show close analogies, it is hypothesized that the effects of ... Cited by 83 - Related articles - BL Direct - All 3 versions
