- ►ahajournals.org SM Grundy, JI Cleeman, SR Daniels, KA … - Circulation, 2005 - Am Heart Assoc The metabolic syndrome is a constellation of interrelated risk factors of
metabolic origin—metabolic risk factors—that appear to directly promote the
development of atherosclerotic cardiovascular disease (ASCVD). 1 Patients ... Cited by 2047 - Related articles - BL Direct - All 11 versions
- ►nih.gov GI Shulman… - Journal of Clinical Investigation, 2000 - Am Soc Clin Investig It is estimated that by the year 2020 there will be approximately 250 million
people affected by type 2 diabetes mellitus worldwide (1). Although the primary
factors causing this disease are unknown, it is clear that insulin ... Cited by 1238 - Related articles - BL Direct - All 9 versions
- ►nih.gov C Weyer, C Bogardus, DM Mott, RE Pratley - Journal of Clinical Investigation, 1999 - Am Soc Clin Investig The pathogenesis of type 2 diabetes involves abnormalities in insulin action,
insulin secretion, and endogenous glucose output (EGO). However, the sequence
with which these abnormalities develop and their relative contributions to ... Cited by 814 - Related articles - BL Direct - All 11 versions
- ►shouxi.net KF Petersen, S Dufour, D Befroy, R Garcia, … - The New England journal of medicine, 2004 - nejm.highwire.org Methods We performed hyperinsulinemic–euglycemic clamp studies in combination
with infusions of [6,6- 2 H 2 ]glucose in healthy, young, lean,
insulin-resistant offspring of patients with type 2 diabetes and insulin- ... Cited by 781 - Related articles - BL Direct - All 14 versions
- ►pharmyaring.com [PDF] SE Inzucchi - Jama, 2002 - Am Med Assoc Context Care of patients with type 2 diabetes has been revolutionized throughout
the past several years—first, by the realization of the importance of tight
glycemic control in forestalling complications, and second, by the ... Cited by 601 - Related articles - BL Direct - All 18 versions
- ►endojournals.org JL Evans, ID Goldfine, BA Maddux, GM … - Endocrine Reviews, 2002 - Endocrine Soc In both type 1 and type 2 diabetes, the late diabetic complications in nerve,
vascular endothelium, and kidney arise from chronic elevations of glucose and
possibly other metabolites including free fatty acids (FFA). Recent ... Cited by 593 - Related articles - BL Direct - All 18 versions
- ►endojournals.org GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - Endocrine Soc The primary genetic, environmental, and metabolic factors responsible for
causing insulin resistance and pancreatic ß-cell failure and the precise
sequence of events leading to the development of type 2 diabetes are not ... Cited by 514 - Related articles - BL Direct - All 6 versions
G Boden, GI Shulman - European Journal of Clinical Investigation, 2002 - interscience.wiley.com Plasma free fatty acids (FFA) play important physiological roles in skeletal
muscle, heart, liver and pancreas. However, chronically elevated plasma FFA
appear to have pathophysiological consequences. Elevated FFA concentrations ... Cited by 487 - Related articles - BL Direct - All 3 versions
- ►shouxi.net TE Graham, Q Yang, M Bluher, A Hammarstedt … - The New England journal of medicine, 2006 - nejm.highwire.org Background Insulin resistance has a causal role in type 2 diabetes. Serum levels
of retinol-binding protein 4 (RBP4), a protein secreted by adipocytes, are
increased in insulin-resistant states. Experiments in mice suggest that ... Cited by 364 - Related articles - BL Direct - All 8 versions
E Ferrannini - Endocrine Reviews, 1998 - Endocrine Soc 1. Clinically, NIDDM is diagnosed on the basis of raised plasma glucose levels
(no other substrate or hormone being considered) that can be controlled without
exogenous insulin (although proneness to ketosis may eventually appear) ... Cited by 308 - Related articles - BL Direct - All 7 versions
