G Xu, G Kwon, CA Marshall, TA Lin, JC … - Journal of Biological Chemistry, 1998 - ASBMB Amino acids have been identified as important signaling molecules involved in
pancreatic β-cell proliferation, although the cellular mechanism responsible
for this effect is not well defined. We previously reported that amino ... Cited by 172 - Related articles - BL Direct - All 4 versions
G Amuthan, G Biswas, SY Zhang, A Klein- … - The EMBO journal, 2001 - pubmedcentral.nih.gov Recently we showed that partial depletion of mitochondrial DNA (genetic stress)
or treatment with mitochondrial-specific inhibitors (metabolic stress) induced a
stress signaling that was associated with increased cytoplasmic-free Ca 2+ ... Cited by 108 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org G Xu, G Kwon, WS Cruz, CA Marshall, ML … - Diabetes, 2001 - Am Diabetes Assoc Recent findings have demonstrated that the branched-chain amino acid leucine can
activate the translational regulators, phosphorylated heat- and acid-stable
protein regulated by insulin (PHAS-I) and p70 S6 kinase (p70 s6k ), in an ... Cited by 85 - Related articles - BL Direct - All 6 versions
- ►physiology.org YP Zhou, JC Pena, MW Roe, A Mittal, M … - American Journal of Physiology- Endocrinology And …, 2000 - Am Physiological Soc To study effects of Bcl-x L in the pancreatic -cell, two transgenic lines were
produced using different forms of the rat insulin promoter. Bcl-x L expression
in -cells was increased 2- to 3-fold in founder (Fd) 1 and over 10-fold in ... Cited by 59 - Related articles - BL Direct - All 3 versions
- ►nih.gov P Maechler, CB Wollheim - The Journal of Physiology, 2000 - Physiological Soc Glucose-induced insulin secretion is determined by signals generated in the
mitochondria. The elevation of ATP is necessary for the membrane-dependent
increase in cytosolic Ca 2+ , the main trigger of insulin exocytosis. Beta ... Cited by 58 - Related articles - BL Direct - All 8 versions
T Nishikawa, E Araki - Antioxidants & Redox Signaling, 2007 - liebertonline.com T HE MITOCHONDRION is believed to be an organelle derived from a genetic
component(s) of microorganisms, and thus its replication, transcription, and
translation system has been developed on its own basis, although several ... Cited by 50 - Related articles - BL Direct - All 4 versions
- ►physiology.org K Minami, H Yano, T Miki, K Nagashima, CZ … - American Journal of Physiology- Endocrinology And …, 2000 - Am Physiological Soc We have established two sublines derived from the insulin-secreting mouse
pancreatic -cell line MIN6, designated m9 and m14. m9 Cells exhibit
glucose-induced insulin secretion in a concentration-dependent manner, ... Cited by 38 - Related articles - BL Direct - All 3 versions
M Jazayeri, A Andreyev, Y Will, M Ward, CM … - Journal of Biological Chemistry, 2003 - ASBMB We report the inducible, stable expression of a dominant negative form of
mitochondria-specific DNA polymerase-γ to eliminate mitochondrial DNA (mtDNA)
from human cells in culture. HEK293 cells were transfected with a plasmid ... Cited by 37 - Related articles - BL Direct - All 4 versions
SM Plaza, LA ND - Altern Med Rev, 2002 - thorne.com Abstract A growing body of evidence has demonstrated a link between various
disturbances in mitochondrial functioning and type 2 diabetes. This review
focuses on a range of mitochondrial factors important in the pathogenesis ... Cited by 34 - Related articles - View as HTML - BL Direct - All 6 versions
M Noda, S Yamashita, N Takahashi, K Eto, LM … - Journal of Biological Chemistry, 2002 - ASBMB To elucidate the mechanism underlying diabetes caused by mitochondrial gene
mutations, we created a model by applying 0.4 µg/ml ethidium bromide (EtBr) to
the murine pancreatic cell line HC9; in this model, transcription of ... Cited by 31 - Related articles - BL Direct - All 3 versions
