- ►fafp.org [PDF] RA DeFronzo - Medical Clinics of North America, 2004 - Elsevier A discussion of the pathogenesis of type 2 diabetes mellitus must start with a
review of mechanisms involved in the maintenance of normal glucose homeostasis
in the basal or postabsorptive state (10–12 h overnight fast) and ... Cited by 692 - Related articles - BL Direct - All 5 versions
M Zander, S Madsbad, JL Madsen, JJ Holst - The Lancet, 2002 - Elsevier 20 patients with type 2 diabetes were alternately assigned continuous
subcutaneous infusion of GLP-1 (n=10) or saline (n=10) for 6 weeks. Before (week
0) and at weeks 1 and 6, they underwent β-cell function tests ... Cited by 614 - Related articles - BL Direct - All 9 versions
DJ Drucker, MA Nauck - The Lancet, 2006 - Elsevier Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone that
stimulates insulin and suppresses glucagon secretion, inhibits gastric emptying,
and reduces appetite and food intake. Therapeutic approaches for enhancing ... Cited by 403 - Related articles - All 10 versions
- ►diabetesjournals.org DJ Drucker - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic
peptide (GIP) exert important effects on β-cells to stimulate glucose-dependent
insulin secretion. Both peptides also regulate β-cell proliferation and ... Cited by 283 - Related articles - All 13 versions
- ►glucagon.com [PDF] DJ Drucker - Gastroenterology, 2002 - Elsevier The glucagon-like peptides (GLP-1 and GLP-2) are proglucagon-derived peptides
cosecreted from gut endocrine cells in response to nutrient ingestion. GLP-1
acts as an incretin to lower blood glucose via stimulation of insulin ... Cited by 253 - Related articles - BL Direct - All 13 versions
Y Li, T Hansotia, B Yusta, F Ris, PA Halban, … - Journal of Biological Chemistry, 2003 - ASBMB Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion and augments β
cell mass via activation of β cell proliferation and islet neogenesis. We
examined whether GLP-1 receptor signaling modifies the cellular ... Cited by 252 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org MS Fineman, TA Bicsak, LZ Shen, K Taylor, E … - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—All three AC2993 regimens led to significant reductions in serum
fructosamine relative to placebo (P ≤ 0.004). Mean reductions ranged from 39
to 46 μmol/l. All AC2993 groups had reductions in HbA 1c ranging from 0.7 ... Cited by 230 - Related articles - BL Direct - All 10 versions
- ►endojournals.org PL Brubaker, DJ Drucker - Endocrinology, 2004 - Endocrine Soc Gut peptides exert diverse effects regulating satiety, gastrointestinal motility
and acid secretion, epithelial integrity, and both nutrient absorption and
disposal. These actions are initiated by activation of specific G protein- ... Cited by 216 - Related articles - BL Direct - All 7 versions
- ►endojournals.org L Farilla, A Bulotta, B Hirshberg, S Li Calzi, … - Endocrinology, 2003 - Endocrine Soc The peptide hormone, glucagon-like peptide 1 (GLP-1), has been shown to increase
glucose-dependent insulin secretion, enhance insulin gene transcription, expand
islet cell mass, and inhibit ß-cell apoptosis in animal models of ... Cited by 216 - Related articles - BL Direct - All 5 versions
DQ Tang, LZ Cao, BR Burkhardt, CQ Xia, SA … - Diabetes, 2004 - Am Diabetes Assoc Efforts toward routine islet cell transplantation as a means for reversing type
1 diabetes have been hampered by islet availability as well as allograft
rejection. In vitro transdifferentiation of mouse bone marrow (BM)-derived ... Cited by 212 - Related articles - BL Direct - All 7 versions
