- ►daegu.ac.kr [PDF] DL Eizirik, T Mandrup-Poulsen - Diabetologia, 2001 - Springer Apoptosis is likely to be the main form of beta-cell death in immune-mediated
diabetes mellitus in ro- dents and possibly in humans. Clarification of the
regulation of beta-cell death could indicate novel sites for therapeutic ... Cited by 320 - Related articles - BL Direct - All 6 versions
MY Donath, J Størling, K Maedler, T Mandrup … - Journal of Molecular Medicine, 2003 - Springer Abstract Pancreatic islet β-cell death occurs in type 1 and 2 diabetes
mellitus, leading to absolute or relative insulin deficiency. β-cell death in
type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes ... Cited by 145 - Related articles - BL Direct - All 3 versions
- ►jbc.org C Bonny, A Oberson, M Steinmann, DF … - Journal of Biological Chemistry, 2000 - ASBMB IB1/JIP-1 is a scaffold protein that interacts with upstream components of the
c-Jun N-terminal kinase (JNK) signaling pathway. IB1 is expressed at high levels
in pancreatic cells and may therefore exert a tight control on signaling ... Cited by 104 - Related articles - BL Direct - All 5 versions
- ►pnas.org AE Karlsen, SG Rønn, K Lindberg, J … - Proceedings of the National Academy of Sciences, 2001 - National Acad Sciences Suppressor of cytokine signaling 3 (SOCS-3) is a negative feedback regulator of
IFN-γ signaling, shown up-regulated in mouse bone marrow cells by the
proinflammatory cytokines interleukin-1β (IL-1β), tumor necrosis ... Cited by 80 - Related articles - BL Direct - All 5 versions
T Mandrup-Poulsen - Biochemical pharmacology, 2003 - Elsevier Failure of insulin producing pancreatic β-cells is a common characteristic of
type 1 (insulin-dependent) and type 2 (insulin non-dependent) diabetes mellitus.
Accumulating evidence suggests that programmed cell death (apoptosis) is ... Cited by 70 - Related articles - All 5 versions
- ►diabetesjournals.org PM Larsen, SJ Fey, MR Larsen, A Nawrocki, HU … - Diabetes, 2001 - Am Diabetes Assoc The intracellular molecular events involved in the β-cell death process are
complex but poorly understood. Cytokines, eg, interleukin (IL)-1β, may play a
crucial role in inducing this process. Protein synthesis is necessary for ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►endojournals.org AE Karlsen, D Pavlovic, K Nielsen, J Jensen, … - Journal of Clinical Endocrinology & Metabolism, 2000 - Endocrine Soc Whereas nitric oxide (NO) production is associated with the toxic effect of
cytokines on rodent pancreatic ß-cells, cytokine-induced apoptosis in human
islets may occur independently of NO. The cysteine protease interleukin ... Cited by 56 - Related articles - BL Direct - All 4 versions
LE Fridlyand, LH Philipson - Diabetes, 2004 - Am Diabetes Assoc Glucose-dependent insulin secretion (GDIS), reactive oxygen species (ROS)
production, and oxidative stress in pancreatic β-cells may be tightly linked
processes. Here we suggest that the same pathways used in the activation of ... Cited by 54 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org [PDF] S Merezak, AA Hardikar, CS Yajnik, C … - Journal of Endocrinology, 2001 - Soc Endocrinology We have demonstrated earlier that a low-protein (8% protein) diet during
gestation alters fetal -cell develop- ment. Here, we investigated the effect of
a low-protein diet as compared with a control (20% protein) diet, during ... Cited by 41 - Related articles - BL Direct - All 8 versions
AE Karlsen, PE Heding, H Frobøse, SG Rønn, M … - Diabetologia, 2004 - Springer Aims/hypothesis. The proinflammatory cytokine IL-1β induces apoptosis in
pancreatic beta cells via path- ways dependent on nuclear factor-κB (NF-κB),
mito- gen-activated protein kinase, and protein kinase C. We recently ... Cited by 25 - Related articles - All 3 versions
