- ►endojournals.org S Matthaei, M Stumvoll, M Kellerer, HU Haring - Endocrine Reviews, 2000 - Endocrine Soc Diabetes mellitus type 2 is a world-wide growing health problem affecting more
than 150 million people at the beginning of the new millennium. It is believed
that this number will double in the next 25 yr. The pathophysiological ... Cited by 205 - Related articles - BL Direct - All 5 versions
- ►fasebj.org G SESTI, M FEDERICI, ML HRIBAL, D … - The FASEB Journal, 2001 - FASEB Insulin receptor substrate (IRS) molecules are key mediators in insulin
signaling and play a central role in maintaining basic cellular functions such
as growth, survival, and metabolism. They act as docking proteins between ... Cited by 155 - Related articles - BL Direct - All 2 versions
- ►jneurosci.org M Schubert, DP Brazil, DJ Burks, JA Kushner, … - Journal of Neuroscience, 2003 - Soc Neuroscience Insulin resistance and diabetes might promote neurodegenerative disease, but a
molecular link between these disorders is unknown. Many factors are responsible
for brain growth, patterning, and survival, including the ... Cited by 113 - Related articles - BL Direct - All 9 versions
- ►physiology.org A Nandi, Y Kitamura, CR Kahn, D Accili - Physiological reviews, 2004 - Am Physiological Soc Type 2 diabetes results from a combination of insulin resistance and impaired
insulin secretion (203). The two abnormalities are intertwined, but in most
individuals the onset of insulin resistance precedes overt -cell ... Cited by 99 - Related articles - BL Direct - All 3 versions
A Parker, J Meyer, S Lewitzky, JS Rennich, G … - Diabetes, 2001 - Am Diabetes Assoc Genome-wide nonparametric linkage analysis of 480 sib-pairs affected with type 2
diabetes revealed linkage to a previously unreported susceptibility locus on
chromosome 18p11. This result improved with stringent subphenotyping using ... Cited by 89 - Related articles - BL Direct - All 6 versions
- ►whitelabs.org [PDF] SA El Mkadem, C Lautier, F Macari, N Molinari, … - Diabetes, 2001 - Am Diabetes Assoc To assess the role of insulin receptor, insulin receptor substrate (IRS)-1, and
IRS-2 genes in insulin resistance, we explored the genomic DNA in women with
polycystic ovary syndrome (PCOS) and a variable degree (mean ± SE) of ... Cited by 69 - Related articles - BL Direct - All 7 versions
MJ Gunter, MF Leitzmann - The Journal of nutritional biochemistry, 2006 - Elsevier There is increasing evidence that dysregulation of energy homeostasis is
associated with colorectal carcinogenesis. Epidemiological data have
consistently demonstrated a positive relation between increased body size ... Cited by 64 - Related articles - All 8 versions
- ►endojournals.org SP Cousin, SR Hugl, CE Wrede, H Kajio, MG … - Endocrinology, 2001 - Endocrine Soc Pancreatic ß-cell mitogenesis is increased by insulin-like growth factor I
(IGF-I) in a glucose-dependent manner. In this study it was found that
alternative ß-cell nutrient fuels to glucose, pyruvate, and ... Cited by 63 - Related articles - All 4 versions
L Hansen, O Pedersen - Diabetes Obesity and Metabolism, 2005 - interscience.wiley.com Throughout the last decade, molecular genetic studies of non-autoimmune diabetes
mellitus have contributed significantly to our present understanding of this
disease's complex aetiopathogenesis. Monogenic forms of diabetes ... Cited by 54 - Related articles - All 4 versions
- ►endojournals.org ML Hribal, M Federici, O Porzio, D Lauro, P … - Journal of Clinical Endocrinology & Metabolism, 2000 - Endocrine Soc Molecular scanning of insulin receptor substrate-1 (IRS-1) revealed several
amino acid substitutions. The most common IRS-1 variant, a Gly to Arg 972
change, is more prevalent among type 2 diabetic patients. In this study we ... Cited by 54 - Related articles - BL Direct - All 4 versions
