- ►diabetesjournals.org AK Busch, D Cordery, GS Denyer, TJ Biden - Diabetes, 2002 - Am Diabetes Assoc Chronic lipid exposure is implicated in β-cell dysfunction in type 2 diabetes.
We therefore used oligonucleotide arrays to define global alterations in gene
expression in MIN6 cells after 48-h pretreatment with oleate or palmitate. ... Cited by 86 - Related articles - BL Direct - All 7 versions
- ►jbc.org L Sheu, EA Pasyk, J Ji, X Huang, X Gao, F … - Journal of Biological Chemistry, 2003 - ASBMB The slower kinetics of insulin release from pancreatic islet beta cells, as
compared with other regulated secretory processes such as chromaffin granule
secretion, can in part be explained by the small number of the insulin ... Cited by 51 - Related articles - BL Direct - All 4 versions
CG Ostenson, H Gaisano, L Sheu, A Tibell, T … - Diabetes, 2006 - Am Diabetes Assoc Exocytosis of insulin is dependent on the soluble N-ethylmaleimide attachment
protein receptor (SNARE) complex proteins in the B-cells. We assessed insulin
release as well as gene and protein expression of SNARE complex protein in ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►endojournals.org PE MacDonald, G Wang, S Tsuk, C Dodo, Y … - Molecular Endocrinology, 2002 - Endocrine Soc Insulin secretion is initiated by ionic events involving membrane depolarization
and Ca 2+ entry, whereas exocytic SNARE (soluble N-ethylmaleimide-sensitive
factor attachment protein receptor) proteins mediate exocytosis itself. In ... Cited by 48 - Related articles - BL Direct - All 3 versions
J Ji, SN Yang, X Huang, X Li, L Sheu, N … - Diabetes, 2002 - Am Diabetes Assoc Cognate soluble N-ethylmaleimide–sensitive factor attachment protein receptor
(SNARE) proteins are now known to associate the secretory vesicle with both the
target plasma membrane and Ca 2+ channels in order to mediate the sequence ... Cited by 45 - Related articles - BL Direct - All 4 versions
- ►endojournals.org HY Gaisano, CG Ostenson, L Sheu, MB … - Endocrinology, 2002 - Endocrine Soc The role of glucotoxicity in dysregulation of islet exocytotic soluble
N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex
proteins and insulin response was explored in the hyperglycemic ... Cited by 40 - Related articles - BL Direct - All 5 versions
Y Kang, X Huang, EA Pasyk, J Ji, GG Holz, … - Diabetologia, 2002 - Springer Aims/hypothesis. Syntaxin-1A (Syn-1A) is known to play a negative regulatory
role in insulin secretion but the precise mechanisms for its action are not
clear. Syn-2,ą3 and ą4 are also present in islet beta cells but their ... Cited by 36 - Related articles - BL Direct - All 4 versions
- ►endojournals.org YM Leung, I Ahmed, L Sheu, RG Tsushima, … - Endocrinology, 2005 - Endocrine Soc We recently reported a transgenic [mouse insulin promoter (MIP)-green
fluorescent protein (GFP)] mouse in which GFP expression is targeted to the
pancreatic islet ß-cells to enable convenient identification of ß-cells ... Cited by 21 - Related articles - BL Direct - All 4 versions
T Saito, S Okada, E Yamada, K Ohshima, H … - Journal of Biological Chemistry, 2003 - ASBMB Although syntaxin 1 is generally thought to function as the primary
target-N-ethylmaleimide-sensitive factor attachment protein receptor required
for pancreatic cell insulin secretion, we have observed that overexpression ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►endojournals.org M Dubois, P Vacher, B Roger, D Huyghe, B … - Endocrinology, 2007 - Endocrine Soc Prolonged exposure of ß-cells to high glucose (glucotoxicity) diminishes
insulin secretion in response to glucose and has been linked to altered
generation of metabolism-secretion coupling factors. We have investigated ... Cited by 23 - Related articles - BL Direct - All 3 versions
