A Flyvbjerg - Diabetologia, 2000 - Springer The development of diabetic nephropathy in patients with Type I (insulin-dependent) and Type
II (non-in- sulin-dependent) diabetes mellitus is still a huge clini- cal problem associated with
increased morbidity and mortality. The mechanisms underlying the develop- ment of ... Cited by 182 - Related articles - BL Direct - All 3 versions
- ►endojournals.org AA Samani, S Yakar, D LeRoith, P Brodt - Endocrine reviews, 2007 - Endocrine Soc IGF-I receptor (IGF-IR) signaling and functions are mediated through the activities of a complex
molecular network of positive (eg., type I IGF) and negative (eg., the type II IGF receptor,
IGF-IIR) effectors. Under normal physiological conditions, the balance between the ... Cited by 167 - Related articles - BL Direct - All 5 versions
- ►asnjournals.org RM Mason, NA Wahab - Journal of the American Society of Nephrology, 2003 - Am Soc Nephrol Diabetes mellitus has recently assumed epidemic proportions, partly due to the 2 to 5% increase
in the incidence of type 1 diabetes in children, but especially due to the global increase in type
2 diabetes (1). Currently as many as 4% of obese adolescents in the United States may ... Cited by 161 - Related articles - BL Direct - All 9 versions
- ►asnjournals.org O Lenz, SJ Elliot, WG Stetler-Stevenson - Journal of the American …, 2000 - Am Soc Nephrol Remodeling of extracellular matrix (ECM) is an important physiologic feature of normal growth
and development. Many diseases have been associated with an imbalance of ECM synthesis
and degradation, which may result in an accumulation of ECM molecules (1). In the ... Cited by 129 - Related articles - BL Direct - All 5 versions
- ►nih.gov F Cornacchia, A Fornoni, AR Plati, A … - Journal of Clinical …, 2001 - Am Soc Clin Investig We found that ROP Os/+ (Os/+) mice had diffuse glomerulosclerosis and glomerular hypertrophy
and that their mesangial cells (the vascular smooth muscle cells of the glomerulus) displayed
an apparent sclerosing phenotype. Since mesangial cells are the major source of scar ... Cited by 99 - Related articles - BL Direct - All 6 versions
SV Mclennan, E Fisher, SY Martell, AK Death, PF … - Kidney International, 2000 - nature.com Diabetic nephropathy is characterized by an accumulation of mesangium matrix that correlates
well with the loss of kidney function. High glucose concentration is known to increase the synthesis
of many matrix components. Recently, we have shown that degradation of matrix also ... Cited by 88 - Related articles - BL Direct - All 4 versions
- ►physiology.org [PDF] F Zheng, A Fornoni, SJ Elliot, Y Guan, MD … - American Journal of …, 2002 - Am Physiological Soc 10 other HighWire hosted articles, the first 5 are: This article has been cited by ... [PDF] [Full
Text] [Abstract] , April 1, 2007; 292 (4): C1361-C1369. Am J Physiol Cell Physiol R. Mishra,
L. Zhu, RL Eckert and MS Simonson TGF-beta-regulated collagen type I accumulation: ... Cited by 84 - Related articles - BL Direct - All 4 versions
D Zhang, M Bar-Eli, S Meloche, P Brodt - Journal of Biological Chemistry, 2004 - ASBMB The matrix metalloproteinase (MMP)-2 has been recognized as a major mediator of basement
membrane degradation, angiogenesis, tumor invasion, and metastasis. The factors that regulate
its expression have not, however, been fully elucidated. We previously identified the type I ... Cited by 71 - Related articles - BL Direct - All 5 versions
PA Sarafidis, LM Ruilope - Am J Nephrol, 2006 - content.karger.com Most of the basic components of the metabolic syndrome, namely type 2 diabetes mellitus,
hypertension, obesity, or low high-density lipoprotein cholesterol levels, apart from being major
risk factors for cardiovascular disease have been also associated with an increased risk ... Cited by 67 - Related articles - BL Direct - All 5 versions
- ►fasebj.org [PDF] L Schaefer, I Raslik, HJ Gröne, E Schönherr, K … - The FASEB Journal, 2001 - FASEB Departments of Internal Medicine and of Physiological Chemistry and Pathobiochemistry, University
of Münster, Münster, Germany; Department of Cellular and Molecular Pathology, German Cancer
Research Center, Heidelberg, Germany, and Institutes of Molecular Biology and Virology, ... Cited by 59 - Related articles - BL Direct - All 4 versions
