DG Hardie, D Carling - European Journal of Biochemistry, 1997 - journal.shouxi.net The LKB1AMPK cascade is switched on by metabolic stresses that either inhibit ATP production
(eg hypoxia, hypoglycaemia) or that accelerate ATP consumption (eg muscle contraction). Any
decline in cellular energy status is accompanied by a rise in the cellular AMP: ATP ratio, ... Cited by 719 - Related articles - Cached - BL Direct - All 6 versions
J Mu, JT Brozinick, O Valladares, M Bucan, MJ … - Molecular cell, 2001 - cell.com Eukaryotic cells possess systems for sensing nutritional stress and inducing compensatory mechanisms
that minimize the consumption of ATP while utilizing alternative energy sources. Such stress
can also be imposed by increased energy needs, such as in skeletal muscle of exercising ... Cited by 485 - Related articles - All 7 versions
RJ Sigal, GP Kenny, DH Wasserman, C Castaneda … - Diabetes care, 2004 - Am Diabetes Assoc For decades, exercise has been considered a cornerstone of diabetes management, along with
diet and medication. However, high-quality evidence on the importance of exercise and fitness
in diabetes was lacking until recent years. The last American Diabetes Association (ADA) ... Cited by 380 - Related articles - BL Direct - All 16 versions
D Milan, JT Jeon, C Looft, V Amarger, A Robic, M … - Science, 2000 - sciencemag.org A high proportion of purebred Hampshire pigs carries the dominant RN mutation, which causes
high glycogen content in skeletal muscle. The mutation has beneficial effects on meat content
but detrimental effects on processing yield. Here, it is shown that the mutation is a ... Cited by 362 - Related articles - BL Direct - All 5 versions
DG Hardie, SA Hawley - Bioessays, 2001 - voh.chem.ucla.edu Summary The AMP-activated protein kinase cascade is a sensor of cellular energy charge, and
its existence provides strong support for the energy charge hypothesis first proposed by Daniel
Atkinson in the 1960s. The system is activated in an ultrasensitive manner by cellular ... Cited by 319 - Related articles - View as HTML - BL Direct - All 3 versions
- ►physiology.org WW Winder, BF Holmes, DS Rubink, EB … - Journal of applied …, 2000 - Am Physiological Soc Muscle contraction causes an increase in activity of 5'-AMP-activated protein kinase (AMPK).
This study was designed to determine whether chronic chemical activation of AMPK will increase
mitochondrial enzymes, GLUT-4, and hexokinase in different types of skeletal muscle of ... Cited by 298 - Related articles - BL Direct - All 5 versions
- ►fasebj.org K Baar, AR Wende, TE Jones, M Marison, LA Nolte, … - The FASEB Journal, 2002 - FASEB Endurance exercise induces increases in mitochondria and the GLUT4 isoform of the glucose
transporter in muscle. Although little is known about the mechanisms underlying these
adaptations, new information has accumulated regarding how mitochondrial biogenesis ... Cited by 293 - Related articles - BL Direct - All 5 versions
- ►cell.com AS Marsin, L Bertrand, MH Rider, J Deprez, C … - Current Biology, 2000 - Elsevier Background: The role of protein phosphorylation in the Pasteur effect—the phenomenon whereby
anaerobic conditions stimulate glycolysis—has not been addressed. The AMP-activated protein
kinase (AMPK) is activated when the oxygen supply is restricted. AMPK acts as an energy- ... Cited by 272 - Related articles - BL Direct - All 12 versions
- ►physiology.org BF Holmes, EJ Kurth-Kraczek, WW … - Journal of Applied …, 1999 - Am Physiological Soc This study was designed to determine whether chronic chemical activation of AMP-activated
protein kinase (AMPK) would increase glucose transporter GLUT-4 and hexokinase in muscles
similarly to periodic elevation of AMPK that accompanies endurance exercise training. ... Cited by 255 - Related articles - BL Direct - All 5 versions
T Hayashi, MF Hirshman, N Fujii, SA Habinowski, LA … - Diabetes, 2000 - Am Diabetes Assoc 5 AMP-activated protein kinase (AMPK) can be acti- vated in response to cellular fuel depletion
and leads to switching off ATP-consuming pathways and switching on ATP-regenerating pathways
in many cell types. We have hypothesized that AMPK is a central mediator of insulin- ... Cited by 244 - Related articles - BL Direct - All 6 versions
