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Scholar Results 1 - 10 of about 45 citing Metz: A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki.... (0.32 sec) 

Differential effects of hyperlipidemia on insulin secretion in islets of Langerhans …

- diabetesjournals.org
I Briaud, CL Kelpe, LM Johnson, POT Tran, V Poitout - Diabetes, 2002 - Am Diabetes Assoc
Chronic elevations in plasma levels of fatty acids (FAs) adversely affect pancreatic β-cell function
in type 2 diabetes. In vitro, we have previously shown that deleterious effects of prolonged exposure
of isolated islets to FAs were dependent on the presence of elevated glucose ...
Cited by 50 - Related articles - BL Direct - All 7 versions

Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects …


PB Jeppesen, S Gregersen, KK Alstrup, K Hermansen - Phytomedicine, 2002 - Elsevier
Extracts of leaves from the plant Stevia rebaudiana Bertoni have been used in the traditional
treatment of diabetes in Paraguay and Brazil. Recently, we demonstrated a direct insulinotropic
effect in isolated mouse islets and the clonal beta cell line INS-1 of the glycoside ...
Cited by 43 - Related articles - All 7 versions

Localization and characterization of the mitochondrial isoform of the nucleoside …


A Kowluru, M Tannous, HQ Chen - Archives of Biochemistry and Biophysics, 2002 - Elsevier
Nucleoside diphosphate kinase (NDPK) catalyzes the transfer of terminal phosphates from nucleoside
triphosphates to nucleoside diphosphates to yield nucleotide triphosphates. The present study
was undertaken to localize and characterize the mitochondrial isoform of NDPK (mNDPK) ...
Cited by 41 - Related articles - BL Direct - All 5 versions

Tacrolimus impairment of insulin secretion in isolated rat islets occurs at multiple …

- endojournals.org
Y Uchizono, M Iwase, U Nakamura, N Sasaki, D Goto, … - Endocrinology, 2004 - Endocrine Soc
Tacrolimus causes posttransplant diabetes mellitus, although the pathogenetic mechanisms
remain controversial. We studied the mechanism of tacrolimus-induced impairment of insulin
secretion using isolated rat pancreatic islets. Tacrolimus caused reductions in DNA and ...
Cited by 37 - Related articles - BL Direct - All 4 versions

The Newly Inbred Cohen Diabetic Rat

- diabetesjournals.org
S Weksler-Zangen, C Yagil, DH Zangen, A Ornoy, HJ … - Diabetes, 2001 - Am Diabetes Assoc
The newly inbred Cohen diabetic rat is an exceptional experimental model of diet-induced type
2 diabetes mellitus that is the result of secondary inbreeding nearly 30 years after it originally
had been established. Animals from the original colony were selectively inbred by ...
Cited by 34 - Related articles - BL Direct - All 5 versions

Overexpression of protein-tyrosine phosphatase PTPσ is linked to impaired …


CG Östenson, AC Sandberg-Nordqvist, J Chen, M … - … and Biophysical Research …, 2002 - Elsevier
The impaired glucose-induced insulin release in type 2 diabetes mellitus may be accounted
for by reduced B-cell ATP/ADP ratio or decreased phosphorylation of proteins regulating exocytosis
of insulin. This, in turn, could be due to enhanced phosphatase activity. Using in situ ...
Cited by 31 - Related articles - BL Direct - All 5 versions

Type 2 Diabetes Causes Remodeling of Cerebrovasculature via Differential …


AK Harris, JR Hutchinson, K Sachidanandam, MH … - Diabetes, 2005 - Am Diabetes Assoc
The risk of cerebrovascular disease is four- to sixfold higher in patients with diabetes. Vascular
remodeling, characterized by extracellular matrix deposition and an increased media-to-lumen
ratio, occurs in diabetes and contributes to the development of complications. However, ...
Cited by 29 - Related articles - BL Direct - All 5 versions

[PDF] Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic …


PB Jeppesen, S Gregersen, SED Rolfsen, M … - …, 2003 - documentosamarillos.net
PB Jeppesen, S. Gregersen, SED Rolfsen, M. Jepsen, M. Colombo, A. Agger, J. Xiao, M.
Kruhøffer, T. Ørntoft, and K. Hermansen ... Stevioside, a glycoside present in the leaves of the
plant, Stevia rebaudiana Bertoni (SrB), has acute insulinotropic effects in vitro. Its ...
Cited by 30 - Related articles - BL Direct - All 17 versions

Identification and characterization of a novel protein histidine kinase in the islet β …


A Kowluru - Biochemical pharmacology, 2002 - Elsevier
Using insulin-secreting cells, we previously demonstrated that specific proteins associated with
the cytosolic, secretory granule, and mitochondrial fractions undergo a novel type of phosphorylation
on their histidine residues. Subsequently, we identified these proteins as the nucleoside ...
Cited by 25 - Related articles - BL Direct - All 6 versions

Adaptive changes in insulin secretion by islets from neonatal rats raised on a high- …

- physiology.org
M Srinivasan, R Aalinkeel, F Song, B Lee, … - American Journal of …, 2000 - Am Physiological Soc
Artificial rearing of neonatal rats on a high-carbohydrate (HC) milk formula resulted in the immediate
onset of hyperinsulinemia. This study examines, in islets of 12-day-old HC rats, adaptive changes
that support the hyperinsulinemic state. Increases in plasma glucagon-like peptide-1 ...
Cited by 20 - Related articles - BL Direct - All 3 versions


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