- ►csus.edu [PDF] WR Heath, FR Carbone - Annual Review of Immunology, 2001 - Annual Reviews According to this simple definition, cross-presentation can involve either class I– or class II–restricted
antigens, although this term has often been associated solely with class I–restricted
antigens. This association is partly historical because the original cross-priming ... Cited by 577 - Related articles - BL Direct - All 7 versions
- ►nih.gov K Maedler, P Sergeev, F Ris, J Oberholzer, … - Journal of Clinical …, 2002 - Am Soc Clin Investig In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to pancreatic β
cells, causing impaired insulin secretion. IL-1β is a proinflammatory cytokine acting during the
autoimmune process of type 1 diabetes. IL-1β inhibits β cell function and promotes Fas- ... Cited by 329 - Related articles - BL Direct - All 7 versions
- ►daegu.ac.kr [PDF] DL Eizirik, T Mandrup-Poulsen - Diabetologia, 2001 - Springer Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes mellitus
in ro- dents and possibly in humans. Clarification of the regulation of beta-cell death could indicate
novel sites for therapeutic intervention in Type I (insulin- dependent) diabetes mellitus. ... Cited by 323 - Related articles - BL Direct - All 6 versions
TJ Wilkin - Diabetologia, 2001 - Springer The definitions need urgent revision. More than half of the patients with Type I diabetes present
in adulthood, when their onset is slow and many do not develop acidosis or require insulin for
many years [1]. Type II diabetes occurs in teenagers [2], some- times with keto-acidosis ... Cited by 240 - Related articles - BL Direct - All 5 versions
MY Donath, J Størling, K Maedler, T Mandrup- … - Journal of Molecular …, 2003 - Springer Abstract Pancreatic islet β-cell death occurs in type 1 and 2 diabetes mellitus, leading to absolute
or relative insulin deficiency. β-cell death in type 1 diabetes is due predominantly to
autoimmunity. In type 2 diabetes β-cell death occurs as the combined consequence of ... Cited by 145 - Related articles - BL Direct - All 3 versions
- ►rupress.org S Turley, L Poirot, M Hattori, C Benoist, D … - Journal of Experimental …, 2003 - jem.rupress.org The prelude to type-1 diabetes is leukocyte infiltration into the pancreatic islets, or insulitis. This
process begins in pancreatic lymph nodes when T lymphocytes reactive to islet ß cells encounter
antigen-presenting cells (APCs) displaying peptides derived from ß cell proteins. We ... Cited by 143 - Related articles - BL Direct - All 6 versions
- ►nih.gov JA Odin, RC Huebert, L Casciola-Rosen, … - Journal of Clinical …, 2001 - Am Soc Clin Investig The close association between autoantibodies against pyruvate dehydrogenase-E2
(PDC-E2), a ubiquitous mitochondrial protein, and primary biliary cirrhosis (PBC) is
unexplained. Many autoantigens are selectively modified during apoptosis, which has ... Cited by 96 - Related articles - BL Direct - All 6 versions
- ►pnas.org K Goudy, S Song, C Wasserfall, YC … - Proceedings of the …, 2001 - National Acad Sciences The development of spontaneous autoimmune diabetes in nonobese diabetic (NOD) mice provides
for their use as a model of human type 1 diabetes. To test the feasibility of muscle-directed gene
therapy to prevent type 1 diabetes, we developed recombinant adeno-associated virus ( ... Cited by 92 - Related articles - BL Direct - All 12 versions
- ►pnas.org JM Wenzlau, K Juhl, L Yu, O Moua, SA … - Proceedings of the …, 2007 - National Acad Sciences Type 1 diabetes (T1D) results from progressive loss of pancreatic islet mass through autoimmunity
targeted at a diverse, yet limited, series of molecules that are expressed in the pancreatic β
cell. Identification of these molecular targets provides insight into the pathogenic process, ... Cited by 91 - Related articles - BL Direct - All 6 versions
MY Donath, JA Ehses, K Maedler, DM Schumann, H … - Diabetes, 2005 - Am Diabetes Assoc A decrease in the number of functional insulin-producing β-cells contributes to the pathophysiology
of type 2 diabetes. Opinions diverge regarding the relative contribution of a decrease in β-cell
mass versus an intrinsic defect in the secretory machinery. Here we review the evidence ... Cited by 86 - Related articles - BL Direct - All 6 versions
