SI Itani, NB Ruderman, F Schmieder, G Boden - Diabetes, 2002 - Am Diabetes Assoc The possibility that lipid-induced insulin resistance in human muscle is related to alterations
in diacylglycerol (DAG)/protein kinase C (PKC) signaling was investigated in normal volunteers
during euglycemic-hyperinsulinemic clamping in which plasma free fatty acid (FFA) levels ... Cited by 523 - Related articles - BL Direct - All 4 versions
- ►endojournals.org OG Kolterman, JB Buse, MS Fineman, E Gaines … - Journal of Clinical …, 2003 - Endocrine Soc Despite the advent of new treatments, glucose control in the type 2 diabetes population is
unsatisfactory. AC2993 (synthetic exendin-4; exenatide), a novel glucose-dependent insulinotropic
agent, exhibited notable antidiabetic potential in two clinical studies in patients with type 2 ... Cited by 277 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org CB Chan, D De Leo, JW Joseph, TS McQuaid, XF Ha, F … - Diabetes, 2001 - Am Diabetes Assoc In pancreatic β-cells, glucose metabolism signals insulin secretion by altering the cellular array
of messenger molecules. ATP is particularly important, given its role in regulating cation channel
activity, exocytosis, and events dependent upon its hydrolysis. Uncoupling protein ... Cited by 207 - Related articles - BL Direct - All 5 versions
P Rorsman, E Renström - Diabetologia, 2003 - Springer Glucose-induced insulin secretion in response to a step increase in blood glucose concentrations
follows a bi- phasic time course consisting of a rapid and transient first phase followed by a slowly
developing and sus- tained second phase. Because Type 2 diabetes involves defects of ... Cited by 205 - Related articles - BL Direct - All 3 versions
LL Nielsen, AA Young, DG Parkes - Regulatory peptides, 2004 - Elsevier Exenatide (synthetic exendin-4), glucagon-like peptide-1 (GLP-1), and GLP-1 analogues have
actions with the potential to significantly improve glycemic control in patients with diabetes. Evidence
suggests that these agents use a combination of mechanisms which may include glucose- ... Cited by 185 - Related articles - All 7 versions
- ►endojournals.org P Gilon, JC Henquin - Endocrine reviews, 2001 - Endocrine Soc Acetylcholine (ACh), the major parasympathetic neurotransmitter, is released by intrapancreatic
nerve endings during the preabsorptive and absorptive phases of feeding. In ß-cells, ACh binds
to muscarinic M 3 receptors and exerts complex effects, which culminate in an increase of ... Cited by 162 - Related articles - BL Direct - All 5 versions
SG Straub, GWG Sharp - Diabetes/Metabolism Reviews - interscience.wiley.com Glucose-stimulated biphasic insulin secretion involves at least two signaling pathways, the KATP
channel-dependent and KATP channel-independent pathways, respectively. In the former, enhanced
glucose metabolism increases the cellular adenosine triphosphate/adenosine ... Cited by 156 - Related articles - BL Direct - All 3 versions
- ►nih.gov FM Ashcroft - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig ATP-sensitive potassium (K ATP ) channels, so named because they are inhibited by intracellular
ATP , play key physiological roles in many tissues. In pancreatic β cells, these channels regulate
glucose-dependent insulin secretion and serve as the target for sulfonylurea drugs used ... Cited by 142 - Related articles - BL Direct - All 14 versions
- ►physiology.org S Seino, T Shibasaki - Physiological reviews, 2005 - Am Physiological Soc Stimulus-secretion coupling is an essential process in secretory cells in which regulated exocytosis
occurs, including neuronal, neuroendocrine, endocrine, and exocrine cells. While an increase
in intracellular Ca 2+ concentration ([Ca 2+ ] i ) is the principal signal, other intracellular ... Cited by 146 - Related articles - BL Direct - All 4 versions
GA Rutter, GDS Xavier, I Leclerc - Biochemical Journal, 2003 - pubmedcentral.nih.gov AMPK (5 -AMP-activated protein kinase) is emerging as a meta- bolic master switch, by which
cells in both mammals and lower organisms sense and decode changes in energy status. Changes
in AMPK activity have been shown to regulate glucose transport in muscle and glucose ... Cited by 141 - Related articles - BL Direct - All 8 versions
