- ►daegu.ac.kr [PDF] DL Eizirik, T Mandrup-Poulsen - Diabetologia, 2001 - Springer Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes mellitus
in ro- dents and possibly in humans. Clarification of the regulation of beta-cell death could indicate
novel sites for therapeutic intervention in Type I (insulin- dependent) diabetes mellitus. ... Cited by 323 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org U Christen, T Wolfe, U Mohrle, AC Hughes, E … - The Journal of …, 2001 - Am Assoc Immnol We report here that islet-specific expression of TNF- can play a dual role in autoimmune
diabetes, depending on its precise timing in relation to the ongoing autoimmune process. In a
transgenic model (rat insulin promoter-lymphocytic choriomeningitis virus) of virally ... Cited by 89 - Related articles - BL Direct - All 3 versions
HE Thomas, R Darwiche, JA Corbett, TWH Kay - Diabetes, 2002 - Am Diabetes Assoc Cytokines have been implicated in pancreatic β-cell destruction leading to type 1 diabetes. In
vitro, a combination of γ-interferon (IFN-γ) and interleukin-1 (IL-1) stimulate inducible nitric oxide
synthase (iNOS) expression in islets, and the resulting increased production of nitric ... Cited by 76 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org U Christen, DB McGavern, AD Luster, MG … - The Journal of …, 2003 - Am Assoc Immnol Infection of the pancreas with lymphocytic choriomeningitis virus results in rapid and differential
expression among CXCR3 chemokines. IFN- -inducible protein of 10 kDa (IP-10), in contrast
with monokine induced by IFN- and IFN-inducible T cell- chemoattractant, is strongly ... Cited by 65 - Related articles - BL Direct - All 6 versions
- ►pasteur.ac.ir [PDF] P Santamaria - Current Opinion in Immunology, 2001 - Elsevier Autoimmune diseases result from complex interactions among different T- and B-lymphocyte
subpopulations that target a rapidly growing number of autoantigens on different cell types. The
etiology of most spontaneous autoimmune disorders, and both the kinetics and hierarchy ... Cited by 63 - Related articles - BL Direct - All 8 versions
- ►direct-ms.org [PDF] U Christen, MG von Herrath - Molecular immunology, 2004 - Elsevier The hypothesis that cross-reactivity between microbial and self determinants recognized by the
adaptive immune system could induce autoimmune diseases is very intriguing. However, definite
proof in humans is very difficult to achieve and evidence is frequently circumstantial. ... Cited by 55 - Related articles - All 6 versions
- ►rupress.org AE Juedes, E Rodrigo, L Togher, LH Glimcher, … - Journal of Experimental …, 2004 - jem.rupress.org The T-box transcription factor T-bet is known to control lineage commitment and interferon- production
by T helper 1 (Th1) CD4 lymphocytes. We report here that T-bet is essential for development
of CD8 lymphocyte-dependent autoimmune diabetes (type 1 diabetes [T1D]) in the rat ... Cited by 50 - Related articles - BL Direct - All 6 versions
- ►endojournals.org M Rotondi, L Chiovato, S Romagnani, M Serio, P … - Endocrine reviews, 2007 - Endocrine Soc Chemokines are a group of peptides of low molecular weight that induce the chemotaxis of different
leukocyte subtypes. The major function of chemokines is the recruitment of leukocytes to inflammation
sites, but they also play a role in tumoral growth, angiogenesis, and organ sclerosis. In ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►nih.gov U Christen, KH Edelmann, DB McGavern, T … - Journal of Clinical …, 2004 - Am Soc Clin Investig We document here that infection of prediabetic mice with a virus expressing an H-2K b –restricted
mimic ligand to a self epitope present on β cells accelerates the development of autoimmune
diabetes. Immunization with the mimic ligand expanded autoreactive T cell populations, ... Cited by 39 - Related articles - BL Direct - All 13 versions
