A Pileggi, RD Molano, T Berney, P Cattan, C Vizzardelli … - Diabetes, 2001 - Am Diabetes Assoc Transplantation of islets of Langerhans represents a viable therapeutic approach for the treatment
of type 1 diabetes. Unfortunately, transplanted islets are susceptible to allogeneic recognition
and rejection, recurrence of autoimmunity, and destruction by local inflammation at the ... Cited by 165 - Related articles - BL Direct - All 5 versions
AK Cardozo, H Heimberg, Y Heremans, R Leeman, … - Journal of Biological …, 2001 - ASBMB Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic -cells.
Cytokines, such as interleukin-1 and interferon- , are putative mediators of immune-induced
-cell death and, under in vitro conditions, cause -cell apoptosis. We have recently shown ... Cited by 159 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org AK Cardozo, M Kruhøffer, R Leeman, T Ørntoft, DL … - Diabetes, 2001 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease resulting from the selective destruction of
insulin-producing β-cells. Cytokines may contribute to pancreatic β-cell death in type 1
diabetes. β-cell exposure to interleukin (IL)-1β induces functional impairment, whereas β- ... Cited by 145 - Related articles - BL Direct - All 4 versions
DR Laybutt, H Kaneto, W Hasenkamp, S Grey, JC … - Diabetes, 2002 - Am Diabetes Assoc Hypertrophy is one mechanism of pancreatic β-cell growth and is seen as an important compensatory
response to insulin resistance. We hypothesized that the induction of protective genes contributes
to the survival of enlarged (hypertrophied) β-cells. Here, we evaluated changes in stress ... Cited by 112 - Related articles - BL Direct - All 5 versions
B Kutlu, AK Cardozo, MI Darville, M Kruhoffer … - DIABETES-NEW …, 2003 - Am Diabetes Assoc Locally released cytokines contribute to -cell dysfunc- tion and apoptosis in type 1 diabetes. In
vitro exposure of insulin-producing INS-1E cells to the cytokines inter- leukin (IL)-1 interferon
(IFN)- leads to a signifi- cant increase in apoptosis. To characterize the genetic networks ... Cited by 91 - Related articles - BL Direct - All 7 versions
A Hoorens, G Stangé, D Pavlovic, D Pipeleers - Diabetes, 2001 - Am Diabetes Assoc Interleukin (IL)-1β is known to cause β-cell death in isolated rat islets. This effect has been attributed
to induction of nitric oxide (NO) synthase in β-cells and subsequent generation of toxic NO
levels; it was not observed, however, in dispersed rat β-cells. The present study ... Cited by 61 - Related articles - BL Direct - All 4 versions
P Dupraz, S Cottet, F Hamburger, W Dolci, E Felley- … - Journal of Biological …, 2000 - ASBMB Insulin-dependent diabetes mellitus is an autoimmune disease in which pancreatic islet β cells
are destroyed by a combination of immunological and inflammatory mechanisms. In
particular, cytokine-induced production of nitric oxide has been shown to correlate with β ... Cited by 51 - Related articles - BL Direct - All 3 versions
J Rasschaert, L Ladrière, M Urbain, Z Dogusan, B … - Journal of Biological …, 2005 - ASBMB Viral infections and local production of cytokines probably contribute to the pathogenesis of Type
1 diabetes. The viral replicative intermediate double-stranded RNA (dsRNA, tested in the form
of polyinosinic-polycytidylic acid, PIC), in combination with the cytokine interferon-γ ... Cited by 41 - Related articles - BL Direct - All 5 versions
- ►daegu.ac.kr [PDF] J Rasschaert, D Liu, B Kutlu, AK Cardozo, M Kruhøffer, … - Diabetologia, 2003 - Springer Aims/hypothesis. Viral infections and local production of IFN-γ might contribute to beta-cell
dysfunction/ death in Type 1 Diabetes. Double stranded RNA (dsRNA) accumulates in the cytosol
of viral-infected cells, and exposure of purified rat beta cells to dsRNA (tested in the form ... Cited by 41 - Related articles - BL Direct - All 4 versions
