MA Atkinson, GS Eisenbarth - The Lancet, 2001 - Elsevier As our knowledge of type 1 (insulin-dependent) diabetes increases, so does our appreciation
for the pathogenic complexity of this disease and the challenges associated with its
treatment. Many new concepts about the pathogenesis of this disorder have arisen. The ... Cited by 568 - Related articles - BL Direct - All 15 versions
HK Akerblom, O Vaarala, H Hyoty, J … - American journal of …, 2002 - interscience.wiley.com * * Hans K. Åkerblom is an emeritus professor of pediatrics, University of Helsinki. He has over
the last two decades studied the epidemiology, etiology and pathogenesis, prediction and prevention
of type 1 diabetes in children. He is the Principal Investigator of the international ... Cited by 143 - Related articles - BL Direct - All 6 versions
M Flodstrom, A Maday, D Balakrishna, MM Cleary, A … - nature immunology, 2002 - ctegd.uga.edu Both genetic and environmental factors are involved in the etiology of autoimmune disease and
viral infections have been implicated as nongenetic triggers of autoimmune reactions to self.
Type 1 diabetes is an immune-mediated disease that results from selective loss of the ... Cited by 98 - Related articles - BL Direct - All 5 versions
V Panoutsakopoulou, ME Sanchirico, KM Huster, M … - Immunity, 2001 - Elsevier The clinical association between viral infection and onset or exacerbation of autoimmune disorders
remains poorly understood. Here, we examine the relative roles of molecular mimicry and nonspecific
inflammatory stimuli in progression from infection to autoimmune disease. Murine herpes ... Cited by 87 - Related articles - BL Direct - All 7 versions
- ►nih.gov MS Horwitz, A Ilic, C Fine, E Rodriguez, N … - Journal of Clinical …, 2002 - Am Soc Clin Investig The induction of autoimmunity by viruses has been attributed to numerous mechanisms. In
mice, coxsackievirus B4 (CB4) induces insulin-dependent diabetes mellitus (IDDM) resembling
the final step of disease progression in humans. The immune response following the viral ... Cited by 83 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org U Christen, DB McGavern, AD Luster, MG … - The Journal of …, 2003 - Am Assoc Immnol Infection of the pancreas with lymphocytic choriomeningitis virus results in rapid and differential
expression among CXCR3 chemokines. IFN- -inducible protein of 10 kDa (IP-10), in contrast
with monokine induced by IFN- and IFN-inducible T cell- chemoattractant, is strongly ... Cited by 65 - Related articles - BL Direct - All 6 versions
F Dotta, S Censini, AGS van Halteren, L … - Proceedings of the …, 2007 - National Acad Sciences Type 1 diabetes is characterized by T cell-mediated autoimmune destruction of pancreatic β
cells. Several studies have suggested an association between Coxsackie enterovirus seroconversion
and onset of disease. However, a direct link between β cell viral infection and islet ... Cited by 68 - Related articles - BL Direct - All 8 versions
- ►jimmunol.org U Christen, MG von Herrath - The Journal of Immunology, 2005 - Am Assoc Immnol The relationship between infections and autoimmunity is complex. Current evidence indicates
that microbes can initiate, enhance, or, conversely, abrogate autoimmunity. In this paper, we
will review experimental examples illustrating mechanisms involved in these three ... Cited by 65 - Related articles - All 5 versions
JK Olson, JL Croxford, SD Miller - Viral immunology, 2001 - liebertonline.com Virus infections have been implicated in the initiation of multiple human autoimmune dis-
eases. This article focuses on reviewing the role of viruses in initiation, progression, and per-
petuation of autoimmune diseases. Various mechanisms by which virus infections can in- ... Cited by 53 - Related articles - BL Direct - All 3 versions
