DG Hardie, SA Hawley - Bioessays, 2001 - voh.chem.ucla.edu Summary The AMP-activated protein kinase cascade is a sensor of cellular energy charge, and
its existence provides strong support for the energy charge hypothesis first proposed by Daniel
Atkinson in the 1960s. The system is activated in an ultrasensitive manner by cellular ... Cited by 319 - Related articles - View as HTML - BL Direct - All 3 versions
SA Hawley, AE Gadalla, GS Olsen, DG Hardie - Diabetes, 2002 - Am Diabetes Assoc Metformin, a drug widely used to treat type 2 diabetes, was recently shown to activate the
AMP-activated protein kinase (AMPK) in intact cells and in vivo. In this study we addressed the
mechanism for this effect. In intact cells, metformin stimulated phosphorylation of the key ... Cited by 241 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org N Musi, MF Hirshman, J Nygren, M Svanfeldt, P … - Diabetes, 2002 - Am Diabetes Assoc Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing
hepatic glucose production and increasing glucose disposal in skeletal muscle; however, the
molecular site of metformin action is not well understood. AMP-activated protein kinase ( ... Cited by 235 - Related articles - BL Direct - All 4 versions
- ►physiology.org WW Winder - Journal of Applied Physiology, 2001 - Am Physiological Soc AMP-activated protein kinase (AMPK) is emerging as an important energy-sensing/signaling
system in skeletal muscle. This kinase is activated allosterically by 5'-AMP and inhibited allosterically
by creatine phosphate. Phosphorylation of AMPK by an upstream kinase, AMPK kinase ( ... Cited by 216 - Related articles - BL Direct - All 5 versions
SB Jørgensen, B Viollet, F Andreelli, C Frøsig, JB … - Journal of Biological …, 2004 - ASBMB We investigated the importance of the two catalytic α-isoforms of the 5′-AMP-activated protein
kinase (AMPK) in 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) and
contraction-induced glucose uptake in skeletal muscle. Incubated soleus and EDL ... Cited by 190 - Related articles - BL Direct - All 4 versions
- ►nih.gov YC Long, JR Zierath - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular
metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake and
lipid oxidation to produce energy, while turning off energy-consuming processes ... Cited by 166 - Related articles - BL Direct - All 9 versions
- ►physiology.org K Sakamoto, LJ Goodyear - Journal of Applied Physiology, 2002 - Am Physiological Soc Physical exercise is a significant stimulus for the regulation of multiple metabolic and transcriptional
processes in skeletal muscle. For example, exercise increases skeletal muscle glucose
uptake, and, after exercise, there are increases in the rates of both glucose uptake and ... Cited by 152 - Related articles - BL Direct - All 3 versions
MA Iglesias, JM Ye, G Frangioudakis, AK Saha, E … - Diabetes, 2002 - Am Diabetes Assoc Exercise improves insulin sensitivity. As AMP-activated protein kinase (AMPK) plays an important
role in muscle metabolism during exercise, we investigated the effects of the AMPK activator
5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) on insulin action in ... Cited by 145 - Related articles - BL Direct - All 5 versions
S Terada, M Goto, M Kato, K Kawanaka, T … - … and biophysical research …, 2002 - Elsevier We previously reported that the peroxisome proliferator-activated receptor γ coactivator-1
(PGC-1) mRNA in rat epitrochlearis muscle was increased after swimming exercise training.
In the present study, we demonstrated further that PGC-1 mRNA expression in the ... Cited by 148 - Related articles - BL Direct - All 5 versions
